Immunity is essential for life, yet the strength of immune responses are not constant throughout the day. This oscillatory immunity reflects an adaptation of organisms to environmental changes that occur through day-night cycles, so as to optimize and concentrate effective responses to the times of maximal environmental threat. In my talk I will discuss our ongoing efforts to uncover the mechanisms by which neutrophils, the most abundant and aggressive of all immune cells, orchestrate temporal immunity. These mechanisms are reflected in diurnal changes in phenotype and function of neutrophils, which we refer to as neutrophil aging. We propose that the existence of a timed response of neutrophils governed by cell-intrinsic and –extrinsic mechanisms suggests that inflammatory disease co-opts ancestral processes to damage tissues.
Disclosure of Interest None declared