Background Interstitial lung disease (ILD) includes a heterogeneous group of disorders that result in diffuse parenchymal lung disease, with overlapping clinical, radiographic, and physiologic manifestations. Several rheumatologic conditions are associated with the development of ILD. There are many patients who are not diagnosed as definite connective tissue disease (CTD). These patients may have an undifferentiated connective tissue disease (UCTD).
Objectives The aim of this study was to compare the prevalence and characteristics of patients with CTD-ILD, UCTD-ILD and Idiopathic pulmonary fibrosis (IPF) in Korean patients.
Methods We study compared the prevalence and characteristics of patients with connective tissue disease-associated interstitial lung disease (CTD-ILD), undifferentiated connective tissue disease-associated interstitial lung disease (UCTD-ILD), or idiopathic pulmonary fibrosis (IPF) between January 2015 and June 2016 in Korea university guro hospital. Clinical characteristics, laboratory tests, and high-resolution CT images were analyzed and compared among three groups.
Results CTD-ILD was identified in 13.0%, UCTD-ILD in 18.2%, and IPF in 68.7% among 307 patients. Female and younger age patients were dominant in CTD-ILD group. Pulmonary symptoms were more common in IPF, while extra-pulmonary symptoms were more common in CTD-ILD and UCTD-ILD group. Patients with CTD-ILD had more abnormal antibody tests than those of UCTD-ILD and IPF. Usual interstitial pneumonia pattern was dominant in HRCT images among three groups.
Conclusions CTD-ILD is not able to be diagnosed accurately in ILD patients. A systematic evaluation of extra-pulmonary symptoms and serologic tests in patients with ILD can identify CTD-ILD, UCTD-ILD, and IPF.
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Disclosure of Interest None declared
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