Background Patients with chronic inflammatory diseases have an increased risk of developing atherosclerosis. Pro-inflammatory cytokines such as interleukin-(IL-)1beta and tumor necrosis factor-(TNF-)alpha, C-reactive protein (CRP) influence on the progression and development of both rheumatoid arthritis (RA) and atherosclerosis.
Methods 620 patients with RA (diagnosis according to ACR /EULAR) from the rheumatology in-patient clinic with the mean age of 43.4±10; 95.4% ACCP – positive patients, activity on DAS (Disease Activity Score) 28 II, III; 85.4% female with the disease duration for about 3–15 years were enrolled in the trial. We assessed the level of IL-1 with the use of ELISA.
Results The constructed model surfaces indicated the interdependence of IL-1, the activity of DAS 28 and the level of LDH in RA patients. The correlative and regressive analysis of the results showed the statistically significant correlation of TG, LDG and markers of inflammation IL-1, DAS 28: p=0.627 (p<0.01), p=0.527 (p<0.01), p=0.712 (p<0.01), p=0.776 (p<0.01) accordingly. The correlation coefficient between hs-CPR and the indicators of the lipid profile revealed similar interconnections.
Conclusions According to the results of modeling, disease activity on DAS and markers of inflammation (IL-1 and hs-CRP) as a markers of the severity of inflammatory process in RA patients are risk factors for developing atherosclerosis. The analysis of inflammation indicators in RA patients allows to assess the risk of developing and progressing atherosclerosis. The data enables to select the best possible personified therapy for such patients at the early stage of the disease.
Disclosure of Interest None declared