Background Antihistone antibodies (AHA) have been linked to Drug-Induced Lupus Erythematosus (DILE) for decades1. However, for some authors this relationship is not so clear and sugest that the presence of these autoantibodies is related to other autoimmune diseases more frequently2,3,4.
Objectives The main objetive of this work was to study the association of AHA with different autoimmune entities (including DILE) and secondarily, look into which clinical manifestations and which autoantibodies are more frequently related to AHA.
Methods We performed a descriptive study. A database was constituted using all patients with AHA+ in any blood analysis between years 2000 and 2016 in the University Hospital Complex of Vigo. The variables of the study were: presence of autoimmune disease, clinical manifestations and related autoantibodies.
ResultsNone of the 73 patients AHA+ developed DILE while almost the 50% of them suffer any other autoimmune disease. We found a high percentage of AHA+ patients with lupus erythematous complications such as arthritis and hematological abnormalities. AntiDNAds antibody was the more frequent coexpressed autoantibody.
AHA detection is not useful as DILE screening.
AHA+ sugest the presence of other autoimmune disease rather than DILE.
AHA+ may be related to lupus erythematous systemic complications.
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Disclosure of Interest None declared