Background Antiphospholipid antibodies (aPL) are a family of autoantibodies that present in a small percentage of the population but occur more commonly in patients with Antiphospholipid syndrome (APS) and Systemic lupus erythematosus (SLE).
Objectives We aimed to determine of the level of anti-β2-glycoprotein I (anti-β2GPI) (IgG and IgM) isotypes and anticardiolipin antibodies (aCL) as inflammatory markers in children with SLE and Juvenile Idiopathic Arthritis (JIA) and figure out their relation to the clinical manifestations and activity of the disease.
Methods This prospective study included one hundred twenty children, sixty five having SLE and fifty five having JIA, their ages range between 4.5 – 16 years (37 males and 83 females).In addition, twenty apparently healthy children of comparable age, sex and nutritional status were used as a control group. All patients and normal controls were subjected to full clinical and laboratory investigations included aCL and anti-β2GPI level (IgG and IgM) measured by a standardized ELISA.
Results IgG isotype of anti-β2GPI was found to be positive in 27.7% and 14.5% for SLE and JIA groups respectively. However IgM isotype of anti-β2GPI was found to be positive in 24.6% and 7.25% for SLE and JIA groups respectively. The mean levels of both IgG and IgM isotypes of anti-β2GPI were found to be significantly increased in comparison to controls (P<0.001) in both SLE and JIA groups. IgG isotype of aCL was found to be positive in 23.1% and 18.2% for SLE and JIA groups respectively. However IgM isotype of aCL was found to be positive in 18.5% and 18.2% for SLE and JIA groups respectively. A significant positive correlation was found between IgM and IgG isotypes of anti-β2GPI and with their corresponding class of aCL in both SLE and JIA groups. A significant positive correlation was found between the elevation of anti-β2GPI (IgG) and thrombocytopenia together with neuropsychiatric disease in SLE. While in JIA elevation of anti-β2GPI was found to be correlated only with elevation of aCL irrespective to clinical or laboratory data.
Conclusions The study reported a higher prevalence of aPL in children with SLE and JIA. Elevated levels of anti-β2GPI (IgG) correlated with thrombocytopenia together with neuropsychiatric disease in SLE.
Disclosure of Interest None declared