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AB0966 The clinical observation of immunoadsorption in treatment of children with refractory autoimmune diseases
  1. P Zeng1,
  2. H Zeng2
  1. 1Department of Pediatric Allergy, Immunology and Rheumatolog, Guangzhou Women and Children's Medical Center, Guangzhou
  2. 2Department of Pediatric Allergy, Immunology and Rheumatology, Guangzhou Women and Children's Medical Center, Gungzhou, China

Abstract

Objectives Explore the clinical efficacy and safety of the immunoadsorption assisted treatment of children with refractory autoimmune diseases.

Methods Use HA280 type resin perfusion machine for four times of whole blood immunoadsorption treatment for one case of a 4-year-old child combined with severe dermatomyositis and pulmonary infection, one case of 9-year-old child with severe allergic purpura combined with gastrointestinal bleeding, intestinal perforation, after intestinal tract partial hepatectomy, one case of 11-year-old child with systemic juvenile idiopathic arthritis combined with head and facial cellulites and macrophage activation syndrome. Observe the improvement of its clinical manifestations, serum immunoglobulin, complement, liver and kidney function, myocardial enzymes, autoantibodies.

Results The children's signs and symptoms improved significantly after treatment of whole blood immunoadsorption, the sensitivity of the adrenal cortex hormones increased, liver and kidney function, myocardial enzymes improved, the levels of serum IGG descended, complement (C3, C4) rose, anti-cyclic citrullinated peptide (CCP) was negative.

Conclusions The whole blood perfusion immunity adsorption treatment is able to to reduce blood plasma IGG, improvement complement C3 and C4 level, eliminates anti-CCP immune body in vivo, reduce the cardiac muscle zymogram and the liver enzyme in a short time, increase sensitivity to the adrenal cortex hormone, alleviate immunological disease's symptom in active stage, have the affirmative function to make the baby pass the dangerous period safely. The child whole blood fills the class immunity adsorption not to present the untoward effect. No untoward effect happened.

Disclosure of Interest None declared

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