Background Sodorimetry is a non-invasive device measures sweat gland dysfunction using electrochemical skin conductance (ESC) of hands and feet and is useful for assessing peripheral small fiber nerve function. Little is known about the dysfunction of peripheral small fiber nerve in patients with gout.
Objectives To evaluate the prevalence and characteristics of small fiber neuropath (SFN) in patients with gout compared with a healty control group and to identify factors associated with SFN in gout.
Methods 80 male patients with well symtom controlled gout (age: 58±12) and 80 healthy controls were enrolled. Each patient was required to fast over 8 hours before blood samples. Serum fasting glucose, fasting insulin, uric acid, serum 25-(OH) D, lipid profiles, Creatinine (Cr) and r-GTP were measured. Body mass index (BMI) and Homeostatic model assessment insulin resistance (HOMA IR) were calculated. Patients already diagnosed with hypertension and diabetes were excluded.
Results The mean feet and hands ESC were significantly lower in the gout group than the control group. Mean Hands ESC was irrelevant to age, BMI, fasting glucose and insulin, HOMA-IR, vit D, uric acid, Cr, and lipids. However, mean feet ESC showed significant correlation with fasting glucose (r=-0.7, p<0.01) and HOMA-IR (r=-0.25, p=0.03).
Conclusions Sudomotor function was significantly lower in patients with gout than the control group. Mean feet ESC was correlated with fasting glucose and insulin resistance in patients with gout. These results suggest that dysfunction of SFN in gout patients is associated with insulin resistance and impaired fasting glucose.
Disclosure of Interest None declared