Objectives The aims of this study are to determine the proportion of patients with ankylosing spondylitis (AS) at high risk for major osteoporotic and hip fractures of Fracture risk assessment (FRAX) in Korean and to determine if a care gap exists for high risk.
Methods This study is a multicenter study including 163 AS patients in 5. All of the AS patients fulfilled the modified New York criteria. The classification of osteoporosis according to WHO criteria was based on T-score ≤ -2.5. The FRAX criteria for high risk of osteoporotic fracture, which is 10-year probability of ≥20% for major osteoporotic fracture or ≥3% for hip fracture, were calculated by the FRAX tool including the bone mineral density (BMD) values. We assessed various demographic factors, clinical and laboratory findings of AS, and medication use for AS and osteoporosis, and then evaluated the risk factors for osteoporotic fracture.
Results The mean age of AS patients was 44.3 years, and 42 patients were female (25.2%) with 23 postmenopausal women 56.1%. Osteoporotic fracture was detected in 16 (9.8%) patients with AS. Among the 16 patients ≥65 years of age, 2 (12.5%) and 8 (50%) were at high risk for a major osteoporotic fracture (10-year probability >20%) and hip fracture (>3%), respectively.
Among patients with BMD measurements (n=106), the 10-year risk of a major osteoporotic fracture and hip fracture calculated with BMD was significantly higher than in those without BMD measurements (P=0.001, P=0.002) respectively. The 10-year risk of a major osteoporotic and hip fracture fracture calculated with BMD was significantly higher than in those without BMD measurements (P<0.001, P=0.003) respectively among male patients with BMD measurements (n=74). There is no statistic difference of the 10-year risk of a major osteoporotic fracture and hip fracture between those calculated with BMD and those without BMD measurements (P>0.05) respectively among female patients (n=32).
Conclusions A substantial gap exists between FRAX with BMD and without BMD in Korean patients with AS.
Disclosure of Interest None declared