Background Osteoprosis is a health problem that if is left untreated,can lead to serious health & economical complications.It is also very common in postmenopausal women. Mineral deficiency, smoking, low BMI, some certain diseases and some medications can also cause osteoprosis. H.Pylori infection can also increase levels of inflammatory cytokines and bone turn over regulatory cytokines,as a result, it is likely that H. pylori infected patients are at increased risk for osteoprosis.
Objectives the present study was done to understanding the association between H.Pylori seropositivity and osteoprosis in postmenopausal women.
Methods The study population consisted of 34 osteoporotic patients and 73 healthy controls. Serum levels of h.pylori antibody (IgA,IgG) were measured by ELISA method.
Results There was no difference in levels of IgA and IgG h.pylori antibody between patients and healthy controls
IgA seropositivity was 70.6% in osteoporotic women and 54.8% in healty women (p value: 0.1). Also H. pylori IgG seropositivity was 82% in osteoporotic women and 75.3% in healthy women (p value: 0.4). We didnot find any correlation between H. pylori seropositivity and bone mineral density in post menopausal women.
Conclusions In this study, we found that Helicobacter pylori infection does not increase the osteoporotic chance and is not a reliable risk factor for osteoporosis. greater sampele size, gastric biopsy to detect atrophic gastritis, bone turn over factors and Cag detection is recommended in order to achieve more accurate results
Shih-Chun Lin, Malcolm Koo, and Kun-Wei Tsai. Association between Helicobacter pylori Infection and Risk of Osteoporosis in Elderly Taiwanese Women with Upper Gastrointestinal Diseases: A Retrospective Patient Record Review, Gastroenterology Research and Practice, 2014;2014:814756.
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Disclosure of Interest None declared