Article Text

AB0850 Helicobacter pylori infection and osteoporosis in post monopausal women
  1. N Abdolahi,
  2. M Aghaei,
  3. M Naghdi
  1. Golestan Rheumatology Research Center, Golestan University of Medical Sciences, Gorgan, Iran, Islamic Republic Of


Background Osteoprosis is a health problem that if is left untreated,can lead to serious health & economical complications.It is also very common in postmenopausal women. Mineral deficiency, smoking, low BMI, some certain diseases and some medications can also cause osteoprosis. H.Pylori infection can also increase levels of inflammatory cytokines and bone turn over regulatory cytokines,as a result, it is likely that H. pylori infected patients are at increased risk for osteoprosis.

Objectives the present study was done to understanding the association between H.Pylori seropositivity and osteoprosis in postmenopausal women.

Methods The study population consisted of 34 osteoporotic patients and 73 healthy controls. Serum levels of h.pylori antibody (IgA,IgG) were measured by ELISA method.

Results There was no difference in levels of IgA and IgG h.pylori antibody between patients and healthy controls

IgA seropositivity was 70.6% in osteoporotic women and 54.8% in healty women (p value: 0.1). Also H. pylori IgG seropositivity was 82% in osteoporotic women and 75.3% in healthy women (p value: 0.4). We didnot find any correlation between H. pylori seropositivity and bone mineral density in post menopausal women.

Conclusions In this study, we found that Helicobacter pylori infection does not increase the osteoporotic chance and is not a reliable risk factor for osteoporosis. greater sampele size, gastric biopsy to detect atrophic gastritis, bone turn over factors and Cag detection is recommended in order to achieve more accurate results


  1. Shih-Chun Lin, Malcolm Koo, and Kun-Wei Tsai. Association between Helicobacter pylori Infection and Risk of Osteoporosis in Elderly Taiwanese Women with Upper Gastrointestinal Diseases: A Retrospective Patient Record Review, Gastroenterology Research and Practice, 2014;2014:814756.

  2. Kakehasi A.M, Mendes C.M.C, Coelho L.G.V, et al “The presence of Helicobacter pylori in postmenopausal women is not a factor to the decrease of bone mineral density,” Arquivos de Gastroenterologia, vol. 44, no. 3, pp. 2007,266–270.

  3. Figura N, Gennari.L, Merlotti et al., “Prevalence of Helicobacter pylori infection in male patients with osteoporosis and controls,” Digestive Diseases and Sciences, vol. 50, no. 5, pp. 2005, 847–852.

  4. Asaoka D, Nagahara A, Hojo M, Sasaki H, Shimada Y, Yoshizawa T, Osada T, Watanabe S. The Relationship between H. pylori Infection and Osteoporosis in Japan. Gastroenterol Res Pract. 2014;2014:340765.


Disclosure of Interest None declared

Statistics from

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.