Background Patients with inflammatory bowel disease [IBD] are at risk for metabolic bone disease. Many studies have identified various risk factors but most of them have involved western patients.
Objectives The aim of this study was to investigate the prevalence and the risk factors for metabolic bone disease in Tunisian IBD patients.
Methods Retrospective study including patients with IBD admitted in our department between January 2011 and December 2015. Demographic and clinical characteristics of patients were analysed. Bone mineral density of the femoral neck, total femur and lumbar spine was quantified by dual-energy X-ray absorptiometry.
Results Among 82 patients followed for IBD (70.7% with Crohn's disease; 29.3% with Ulcerative colitis), a bone densitometry was performed in 56% of cases (n=46). 16 patients have osteopenia and 7 had osteoporosis, as assessed by T-score. Univariate analysis showed that Crohn'n disease in particular ileal disease, high steroid dose and the presence of extra-intestinal manifestations were significantly associated with a low bone mineral density (for all p<0.05). In the other hand, IBD duration since diagnosis, sexe, tabagism were not associated with bone loss.
In multivariate regression analysis, risk factors for decreased bone mineral density were IBD duration since diagnosis, high steroid dose, ileal crohn's disease and extra-intestinal manifestations.
Conclusions In our Tunisian cohort of IBD patients, Crohn's disease, high steroid dose and extra-intestinal manifestations were associated with increased risk for metabolic bone disease. High risk patients should be identified and appropriate therapies should be started early to improve long term quality of life.
Disclosure of Interest None declared