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AB0824 The method of calculating the probability of osteopenia in patients with multifocal atherosclerosis
  1. AN Kokov1,
  2. VL Masenko1,
  3. SE Semenov1,
  4. TA Raskina2,
  5. OL Barbarash1
  1. 1Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases
  2. 2Kemerovo state medical academy of Federal Agency of Healthcare and Social Development, Kemerovo, Russian Federation

Abstract

Objectives To determine probability of the presence of osteopenic syndrome in patients with multifocal atherosclerosis based on the multislice computed tomography (MSCT) evaluation of vascular calcification.

Methods 186 male (60±6,7 years) with multifocal atherosclerosis. All the patients underwent the measurement of BMD with X-ray absorptiometry. Moreover, calcium scores (CS) of coronary and brachiocephalic arteries were obtained using Agatston method.

Results Among the patients had a high prevalence of osteopenia syndrome (87.1%). According to X-ray absorptiometry T-score values of lumbar vertebrae -1.07 [-1.54; -0.40], T-score of the proximal femur -2.01 [-2.71; -1.49]. We also found a large amount of calcification of the coronary arteries according MSCT: calcium score (CS) 471.8 [118.2; 916,8]. Calcification of the carotid arteries in patients of the study group was less pronounced: CS 113.9 [44.5; 300.8], but noted significant direct relationship between the degree of calcification of different vascular beds (r=0,35, p<0,05). We have data on the significant inverse association between bone density and a coronary artery calcification (r=-0,29, p<0,05), and the carotid artery (r=-0,22, p<0,05) by using Spearman rank correlations. Factors that affect the probability of osteopenic syndrome (according X-ray absorptiometry) in patients with known rates of calcification of the coronary and carotid arteries were obtained by regression analysis. These factors were coronary CS (p=0.012), carotid CS (p=0.034), the mass of calcifications of the carotid arteries (p=0.025) and the presence of a stenosis of the carotid arteries (p=0.026). The predictive model for estimating the probability of the presence of osteopenia in patients with multifocal atherosclerosis has been is designed using regression coefficients of each of the factors. As a result, ROC-analysis of the area under the ROC-curve for this prediction model was 0.792 (p=0.0001). The model was tested in the study sample. The specificity of the model was 72.1%, sensitivity of the model was 80.2%.

Conclusions The study results suggest that indicators of calcification of the carotid and coronary arteries resulting from a routine examination by MSCT of patients with multifocal atherosclerosis have a high predictive capacity for assessing the probability of the presence of osteopenic syndrome in this category of patients.

Disclosure of Interest None declared

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