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AB0820 Frequency of osteoporosis and associated risk factors in mexican patients with rheumatoid arthritis
  1. AN Rangel-Botello1,2,
  2. A Gallegos-Posada2,
  3. F Jasso-Άvila2,
  4. D Ramos-Bello1,2,
  5. C Villa-Calderόn3,
  6. MU Martínez-Martínez1,2,
  7. C Abud-Mendoza1,2
  1. 1Rheumatology, Hospital Central “Dr. Ignacio Morones Prieto”
  2. 2Faculty of Medicine, Autonomous University of San Luis Potosí, San Luis Potosí
  3. 3Faculty of Medicine, Autonomous University of Aguascalientes, Aguascalientes, Mexico

Abstract

Background The risk of osteoporosis in patients with rheumatoid arthritis (RA) is well described and may be associated with genetic and environmental factors. The frequency of generalized osteoporosis in different studies is variable.

Objectives The aim of the study was to investigate the frequency of osteoporosis as well as to describe the risk factors in RA population.

Methods Retrospective study, including patients with RA who had at least 2 densitometries in their follow up. We collected demographic characteristics, use of glucocorticoids (GC), other medications and antibody profile. Variables were compared between groups with or without osteoporosis. The frequency of osteoporosis was calculated according to the T-score and logistic regression was performed to explore the association of osteoporosis and relevant variables. Statistical analysis was performed using R software version 3.2.1. Baseline characteristics were compared between groups of patients (osteoporosis in the lumbar spine, femoral neck and hip) defined according to the T-score results. We used x2 or Fisher test for categorical variables as appropriate and Wilcoxon test for continuous variables. A logistic regression model was used to explore the relationship between osteoporosis and variables that could contribute as risk factors.

Results One hundred and five patients were included, 96.2% were women, RA evolution of 7 (IQR 8) years. The frequency of osteoporosis was: lumbar spine 55.2%, hip 12%, and femoral neck 25.7%. Patients with lumbar spine osteoporosis had higher age (62 vs 58 years, p=0.13), lower weight (57 vs 63.8 kg, p=0.00004) and higher FRAX scores (26.5 vs 11.5, p=0.004; 8.5 vs 2.4, p=0.02). The associated risk factors were: weight (OR 1.09, 95% IC 1.03–1.15, p=0.001), GC use (OR 4.36, 95% IC 1.0–19.89, p=0.049), menopause (OR 22.78, 95% IC 2.73–190.12, p=0.003). There was no association with disease activity (DAS28-ESR) (OR 0.64, 95% IC 0.42–0.96, p=0.049).

Multivariate logistic regression analysis of osteoporosis associated factors

Conclusions The frequency of lumbar spine osteoporosis in our population was similar to that reported in previous studies (38.9%>50%). In our study only significant association with weight, GC use and menopause was observed

References

  1. Deodhar AA, Woolf AD. Bone mass measurement and bone metabolism in rheumatoid arthritis: a review. Br J Rheumatol. 1996;35:309–22.

  2. Haugeberg G, et al. Bone mineral density and frequency of oteoporosis in female patients with rheumatoid arthritis: results from 394 patients in the Oslo County Rheumatoid Arthritis register. Arthritis Rheum. 2000;43:522–30.

  3. Guler-Yuksel M, et al. Bone mineral density in patients with recently diagnosed, active rheumatoid arthritis. Ann Rheum Dis. 2007;66:1508–12.

  4. Peng J, et al.Bone Mineral Density in Patients With Rheumatoid Arthritis and 4-Year Follow-up Results.J Clin Rheumatol 2016;22: 71–74.

References

Disclosure of Interest None declared

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