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AB0631 The clinical consequences presence of ANTI-PM/SCL antibodies in systemic sclerosis
  1. E Wielosz,
  2. M Dryglewska,
  3. M Majdan
  1. Department of Rheumatology and Connective Tissue Diseases, Medical University of Lublin, Lublin, Poland

Abstract

Background Anti-PM/Scl (a-PM/Scl) antibodies are found in different systemic autoimmune disease such as polymyositis, dermatomyositis, systemic sclerosis (SSc), and overlap syndromes. According to literature they are detected in about 2% of patients with SSc, but their presence are more common in SSc with myositis overlap. Features positively associated with the presence of a-PM/Scl antibodies included younger age at disease onset, skeletal muscle involvement, calcinosis, inflammatory arthritis, and overlap disease. On the other hand interstitial lung disease and gastrointestinal symptoms were less frequent in SSc patients with a-PM/Scl.

Objectives The aim of the study was to assess the clinical consequences presence of a-PM/Scl antibodies in patients with SSc.

Methods The study was performed in 126 European Caucasian SSc patients (98-female and 28-male) hospitalized consecutively in the Department of Rheumatology and Connective Tissue Diseases. Patients fulfilled the ACR classification criteria of SSc (59 have diffuse cutaneous SSc and 67 limited SSc). The study group were studied according to the presence of a-PM/Scl antibodies applying commercial test – EUROLINE Systemic Sclerosis Profile. Detection and interpretation of results was carried out electronically using the specific program Euroimmun– EUROLINEScan. The subtype of SSc, incidence of internal organ involvement and serological profile were determined in the whole group. Due to the presence of a-PM/Scl antibodies, patients were divided into two groups a-PM/Scl (+) SSc - 22 pts and a-PM/Scl (-) SSc- 104 pts.

Results a-PM/Scl antibodies were detected in 22/126 patients with SSc (17,5.%) We showed a significant positive association with a-PM/Scl antibodies and myalgia or myosistis (p=0,0379), contractures (p=0,0002) and prevalence of overlap syndrome (p=0,0142). There were no relationship between the presence of a-PM/Scl antibodies and subtypes of SSc, other organ involvement, digital ulcers or calcinosis.

Conclusions In SSc anti-PM/Scl antibodies are frequently associated with myalgia or myositis, contractures and overlap syndrome.

Disclosure of Interest None declared

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