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AB0574 Venous involvement in behcet's disease: a retrospective analysis of 75 cases
  1. L Belhadj,
  2. A Hariz,
  3. I Boukhris,
  4. I Kechaou,
  5. S Azzabi,
  6. L Ben Hassine,
  7. E Cherif,
  8. N Khalfallah
  1. Internal medecine B, Charles Nicolle Hospital, Tunis, Tunisia

Abstract

Objectives Behcet's disease (BD) is a chronic multisystem inflammatory disease characterized by recurrent mouth and genital ulcerations. The vascular involvement varies from 7, 7 to 43% depending on ethnicity. Venous lesions are the most frequent vascular manifestation in BD. In this study, we looked at the pattern and outcome of venous events in BD.

Methods Seventy five patients, who fulfilled the criteria of the International Study Group for diagnosis of BD, were recruited. We studied the characteristics of patients with thrombotic venous events. Clinical data parameters were recorded, including age at onset, the vascular and extra-vascular manifestations of the disease.

Results Twenty six from 75 patients had vascular event. Twenty three of these patients had a venous event. The mean age of the patients at the first venous event was 32 years. There were 22 males and 4 females. The first venous event occurred before BD diagnosis in one case and in the same time of onset of the disease in two cases. In the other cases, venous event occurred in patients followed for BD and the mean disease duration was 5, 82 years. The mean number of recurrence of venous events was 1, 46. Deep vein thrombosis was the most frequent single vascular event (76, 92%). The most frequent localizations were in legs (23 cases). Four patients had cerebral vein thrombosis. A pulmonary venousinvolvement, a Budd-Chiari syndrome,an inferior and superior vena cava syndrome and arms thrombosis were found in only one case each one. An arterial event was associated in 2 cases. An association with ocular manifestations was observed in 26, 9% patients and neurologic manifestations in 11, 53%.

Conclusions Although there is no agreement on the frequency rate of the vascular lesions in the littérature, most the vascular lesions in the litterature, most of the reported series indicate that the venous lesions are by far, more common than the arterial lesions. Kabbaj et al. reported 85% venous, 10% arterial and 5% mixed arterial and venous involvment which is similar to the reported frequency in our patients.

In conclusion, the frequency of vascular complications of BD in our patients is similar to those reported around the world.

References

  1. Seyahi E. Behçet's disease: How to diagnose and treat vascular involvement.

  2. Best Pract Res Clin Rheumatol. 2016 Apr;30(2):279–295.

  3. Seyahi E. Behçet's disease: How to diagnose and treat vascular involvement.Best Pract Res Clin Rheumatol. 2016 Apr;30(2):279–295.

  4. Balta S, Balta I, Ozturk C, Celik T, Iyisoy A. Behçet's disease and risk of vascular events. Curr Opin Cardiol. 2016 Jul;31(4):451–7.

  5. Seyahi E, Cakmak OS, Tutar B, Arslan C, Dikici AS, Sut N, Kantarci F, Tuzun H, Melikoglu M, Yazici H. Clinical and Ultrasonographic Evaluation of Lower-extremity Vein Thrombosis in Behcet Syndrome: An Observational Study. Medicine (Baltimore). 2015 Nov;94(44):e1899.

References

Disclosure of Interest None declared

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