Objectives Kawasaki disease (KD)is a kind of febrile disorder without definite etiology. Coronary artery aneurysms are the major complication of Kawasaki disease (KD). r11le pathogenesis of the vascular damage remains unknown.This study Wfl8 conducted to explore the pathophysiological role of E-selectin (ES), CMatrix metalloproteinase 9 (MMP-9) in KD.and to look for the evidenee of direct relationship between the plasma levels of ES,MMP-9 and the incidence of the coronary artery lesion (CAL).
Methods Soluble ES and MMP-9,were measured in 68 patients with KD,20 patients with febrile disease and 20 healthy children by using double antibody sandwich enzyme linked immunosorbent assay (ELISA).Patients with KD were separated into acute phase group, subacute phase group, recovery phase group. coronary artery lesion group (CAL), non-coronary artery lesion group (NCAL).
Results KS and MMP-9 levels in the acute phase group,subacute phase group were significantly higher than those in the healthy group. Plasma ES and MMP-9 levels of CAL group were significanfly higher than those of NCAL group in acute phase. ne peak level of ES and MMP-9 appeared in the acute phase.There Was a significant correlation between KS and MMP-9 levels in KD patients (r=0.643, P<0.01).
Conclusions the increase of plasma PS and ES levels in KD acute phase and subacute phase might play an important role in the pathophysiology of the VasCUlax damage.KS and MMP-9 may potentially be a predictor of CAL in patients.
Disclosure of Interest None declared