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AB0520 The role of leptin in sjogren's disease
  1. M Erdoğan1,
  2. ME Tezcan2,
  3. K Başak3
  1. 1Internal medicine division of Rheumatology, Cerrahpaşa Medical Faculty
  2. 2Internal medicine division of Rheumatology
  3. 3Pathology, Dr. Lürfi Kırdar Kartal Training and Research Hospital, Istanbul, Turkey

Abstract

Background Sjogren's disease (SD) is a multisystemic disease mostly manifest with sicca symptoms. Lympocytic infiltration of the glandular and extra glanduler organs is the dominant pathologic feature of the disease. Multiple stimulators were accused in the pathogenesis of SD. Leptin, an endogenous peptide, involves in various metabolic processes as well as influence immune system (1). Increased serum leptin level is observed in patients with autoimmune diseases such as SD, systemic lupus erythematosus and rheumatoid arthritis when compared to healthy controls (2).

Objectives Even if serum leptin level increases in the patient with SD, there is no data about its effect on exocrine glands. We aimed to compare density of leptin in the salivary gland of SD patients with control group. Furthermore we evaluted the relation between intensity of lympocytic infiltration and density of leptin in the salivary glands of SD patients

Methods We applied leptin immunostain to minor salivary glands samples of 24 SD patientss,who were fullfilled American College of Rheumatology Sjögren's Disease Classification Criteria (ACR-SDCC) and 19 patients who undergo minor salivary gland biopsy due to clinically on suspicion of SD but not fullfilling the ACR-SDCC and had no lymphocytic focus on biopsy. Herein,leptin density in acinar and ductal structures of the salivary glands were evaluated in both groups.Moreover, minor salivary gland samples of SD patients were also assessed for relationship between focus score, disease progression (evaluated with SSDAI) and leptin immunostaining.

Results Demographic features of both group were similar. Furhermore, there were no difference in leptin staining features of both group.Additionally, we found that higher focus score (>2) was associated with more diffuse leptin staining and higher SSDAI scores related with diffuse acinar staining.

Conclusions Different leptin staining features in higher focus score and higher disease activity might indicate the role of leptin especially in more significant disease. Leptin may locally stimulate chemotaxis and activate infiltration of glands with inflammatory cells. We suggested further studies aimed to understand autocrine effect of leptin and evalute its role in SD pathogenesis

References

  1. Stofkova, A. Leptin and adiponectin: from energy and metabolic dysbalance to inflammation and autoimmunity. Endocrine regulations, 2009, 43.4: 157–168.

  2. Vadacca, Marta, et al. Leptin in immuno-rheumatological diseases. Cellular & molecular immunology, 2011, 8.3: 203–212.

References

Disclosure of Interest None declared

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