Objectives We assessed correlations of smoking habits and alcohol consumption with disease activity or damage in patients with systemic lupus erythematosus (SLE).
Methods A total of 505 patients with SLE were enrolled in the KORean lupus Network (KORNET) SLE registry from January 2014 to January 2016. Disease activity and organ damage were measured by the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) damage index, respectively. Multivariate logistic regression analysis was used to analyze associations with cutaneous lesions.
Results There are no differences in SLEDAI-2K and SLICC/ACR damage indexes according to either smoking status or alcohol consumption. More frequent cutaneous damage was observed in current alcohol drinkers compared to non-current alcohol drinkers (p=0.020). Cutaneous damage was significantly associated with alcohol consumption [Odds ratio (OR) 4.048, 95% confidence interval (CI) 1.251 – 12.102, p=0.020]. Both low (1–5 glasses/week) and high (≥6 glasses/week) amounts of alcohol consumption had a significant impact on cutaneous damage compared to the absence of current alcohol consumption (p=0.033 and p=0.027, respectively). Pairwise comparison of alcohol consumption and smoking status with cutaneous damage showed that only alcohol consumption was significantly associated with the presence of cutaneous damage, compared to non-current alcohol consumption and non-current smoking (OR 3.513, 95% CI 1.130 – 10.920, p=0.030).
Conclusions Current alcohol consumption, but not smoking, might influence the development of cutaneous damage in patients with SLE.
Disclosure of Interest None declared