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AB0474 Thyroid dysfunction in systemic lupus erythematosus: its impact as a cardiovascular risk factor
  1. A Mabrook,
  2. MI Abd elkareem,
  3. MM Rayan
  1. Rheumatology, Alazhr University, Assuit, Egypt

Abstract

Background Systemic lupus erythematosus (SLE) is an autoimmune disease caused by immune system–mediated tissue damage Thyroid function abnormalities and thyroid autoantibodies have been frequently described in patients with rheumatologic autoimmune diseases, such as SLE

Objectives The aim of the study Was to assess thyroid function and anti-thyroid antibodies in SLE patients and evaulate the effects of the thyroid dysfunction on the clinical parameters, disease activity and assess its impact as a cardiovascular risk factor.

Methods A total number of Fifty SLE female patients were selected, Triglycerides (TG), total cholesterol (TC), LDL and high density lipoprotein (HDL).Thyroid Stimulating Hormone (TSH),serum freeT3 (FT3), freeT4 (FT4).Serum thyroid peroxidase antibodies (TPOab) and serum thyroglobulin antibodies (TGab) erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), IMT (intima-media thickness) of the carotid arteries and Echocardiography was done for all patients

Results There is a statistically significant correlation between SLE and thyroid disorder p. value<0.05.clinical hypothyroidism was the most common abnormality presented followed by subclinical hypothyrodism.There is a statistically significant correlation between IMT and thyroid disorder p. value<0.05.There is a statistically significant correlation between cardiac valves disorder and thyroid disorderT, we found a statistically significant correlation between pericardial effusion and thyroid disorder p. value<0.05.

Conclusions we conclude that thyroid disorder is more common in lupus patients especially those in exacerbation and +ve for antithyroid Ab and Those with thyroid dysfunction had increased cardiovascular risk. These patients should be investigated for Lipid profile echocardiography and neck US for detection of early atherosclerosis and other CVD Those with thyroid dysfunction had increased cardiovascular risk.

References

  1. Nakisa R, Mesbah Sh, Eskandar K-S, and Nazarinia M.A,(2015).

  2. The Prevalence of Thyroid Dysfunction in Patients With Systemic Lupus Erythematosus. Iran Red Crescent Med J. 2015 December; 17(12): e17298.

  3. Tektonidou MG, Anapliotou M, Vlachoyiannopoulos P, Moutsopoulos HM. (2004) Presence of systemic autoimmune disorders in patients with autoimmune thyroid diseases. Ann Rheum Dis. 2004;63(9):1159–61. doi: 10.1136/ard.2004.022624.

References

Disclosure of Interest None declared

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