Background Intravenous MSC infusion has been reported occasionally in SS treatmen and Immune Thrombocytopenia ttreament. To our knowledge,there is rare report of allogeneic unrelated-donor intravenous MSC infusion in SS with thrombocytopenia without immunosuppresive induction of MSC transplantation.
Objectives To report the case of a Sjogren syndrome with refractory thrombocytopenia treated with MSC infusion. To review the current literature on intravenous MSC infusion for SS.
Methods Literature review and multidisciplinary discussion were thoroughly performed before treatment protocol was approved by institutional ethics committee and patient and family signed informed consent form.
Results A 48 year-old female with a 2-year history of SS, manifested by severe thrombocytopenia (PLT 14–30*10E9/L, after each injection of recombinant human interleukin 11, platelets can be transiently recovered.) refractory to Methylprednisolone, methotrexate, azathioprine and cyclophosphamide received Four infusions (Once a month) of allogeneic unrelated-donor 2x106/Kg MSC. After two infusiong of MSC, the PLT increased gradually to greater than 100*10E9/L. After 1 year of follow-up, Platelet counts remained normal.
Conclusions These results suggest that mesenchymal stem cells may be a therapeutic strategy for Sjogren syndrome with Refractory thrombocytopenia patients. Larger studies are needed to validate clinical efficacy and safety and to standardize treatment protocol of MSC infusion in SS.
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Disclosure of Interest None declared