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AB0430 Leflunomide as a second line dmard after methotrexate has limited impact on rheumatoid arthritis in real life
  1. G Weigt,
  2. A Erler,
  3. M Aringer
  1. Medicine III, University Medical Center TU Dresden, Dresden, Germany

Abstract

Background If rheumatoid arthritis (RA) is not in remission or at least low disease under methotrexate (MTX), leflunomide is an approved conventional synthetic DMARD, which is commonly used in some countries.

Objectives To investigate in a real life situation whether patients with RA benefit from instituting leflunomide after methotrexate.

Methods The clinical data of all RA patients who had at least once received leflunomide, and who agreed to the pseudonymized analysis of their data (approved by the local ethics committee), were analyzed from the time of leflunomide initiation on to the time of stopping leflunomide or the last visit in 2015, which ever came first.

Results In total, 145 RA patients treated with leflunomide were identified. Of these, 87 received leflunomide after MTX had failed as a first line DMARD, and 8 received leflunomide as a first line DMARD. 50 patients had another first line therapy. Of the first line leflunomide patients 3 (38%) were still on leflunomide at the last visit, as compared to 7 of the 44 patients (16%) who were switched from MTX to leflunomide, and 0 of the 27 patients in whom leflunomide was added to MTX (p<0.01 vs 1st line leflunomide). For leflunomide monotherapy, 29% and 19% were still on the drug after 24 and 48 months, respectively, as compared to 14 and 0% under the combination with MTX. Of all patients who started leflunomide, remission (at least low disease activity) as per CDAI (≤2.8 (≤10)) was reached by 23% (57%) 3 months, 20% (40%) 6 months, and 16% (34%) one year after initiating leflunomide monotherapy, with corresponding percentages of patients of 39% switched to other approaches at six months and of 60% switched at one year. Under the combination of leflunomide and MTX, remission (at least low disease activity) was seen in 18% (53%) at 3 months, 20% (37%) at 6 months, and 8% (20%) at one year, and 55% and 71% had switched to other modes of action at six months and one year, respectively. Gastrointestinal and mucocutaneous adverse events and hypertension were common, and 4 our patients experienced serious bacterial infections.

Conclusions Leflunomide constitutes a longer term option for a subgroup of RA patients with contraindications to MTX or after MTX failure. After one year, leflunomide had led to sustained acceptable disease control in approximately one third of the patients, but only in one in five under leflunomide combined with MTX. These results are supportive of the EULAR recommendations that patients should be switched to a second conventional DMARD in the absence of predictors of bad outcome only. If leflunomide is initiated, the patients need to be followed closely for potential secondary loss of efficacy.

Disclosure of Interest None declared

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