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AB0354 Prevalence of signs of connective tissue dysplasia in patients with rheumatoid arthritis and characteristics of the course of combined pathology
  1. R Demidov,
  2. S Lapshina,
  3. L Myasoutova
  1. Kazan State Medical University, Kazan, Russian Federation

Abstract

Background Connective tissue dysplasia (CTD) has a common pathogenesis with rheumatoid arthritis (RA). Question of peculiarities in such combination remains little known.

Objectives To analyze the peculiarities of RA in patients with signs of CTD.

Methods Among the 107 patients with RA, seen in the rheumatology departments in Kazan city, 18 (16.8%) patients (15 women and 3 men, mean age 47,9±12,89 years) with reliable signs of CTD were selected, identified clinically and the analysis of their documentation was performed. By DAS28 low RA activity was detected in 1 (5.6%) patients, average - 13 (72.2%), high - 4 (22.2%). The clinical-laboratory and instrumental methods of diagnosis, standardized and independently developed questionnaire for the presence of CTD in selected group of patientswere used

Results The most frequently following signs of CTD syndrome - vegetative-vascular dystonia - 14 (77.7%), myopia - in 9 (50%), mitral valve prolapse- in 6 (33.3%), small heart abnormalities - in 8 (44.4%), flat feet - 6 (33.3%), scoliosis - in 5 (27.7%), hyperkyphosis - in 2 (11.1%), hypermobility of joints - in 2 (11 1%), anomaly of kidney structure- in 2 (11.1%), rhythm and conduction disturbances- in 7 (38.8%). Osteoporosis was observed in 11 (61.1%) patients.

We select two group of patients: the first (n=9) from 1 to 5 CTD signes and the second (n=9) – from 6 to 9 dysplasia symptoms. In the second group RA activity by DAS28 was significantly (p≤0.05) higher (4.52±1,20) than in the first (DAS28 =3.95±0.81). Obtained differences in RA activity, depending on the availability of myopia (DAS28 =4,68±0,87) or its absence (DAS28 =3,78±1,06); flatfoot (DAS28 =4,53±1,05) or its absence (DAS28 =4,04±1,02) were evaluated. A significant (p≤0.05) difference was found in patients with osteoporosis, the availability for activity (DAS28 =4.68±0.97), pain intensity VAS (1,44sm ± 6.90), compared with normal bone density tissue (DAS28 =3,36±0,36, pain VAS =5,83±2,22 cm).

Conclusions Among patients with RA CTD signes occur more frequently than in the population (16.8% versus 10%). The most frequently detected are myopia, vegetative-vascular dystonia, cardiac diseases, osteoporosis. Patients with signs of dysplasia had a trend towards a higher activity of RA.

Disclosure of Interest None declared

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