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AB0333 Use of biological dmards, but not of conventional synthetic dmards or steroids, may be relevant to increased energy intake in patients with rheumatoid arthritis
  1. K Masuko1,2,
  2. Y Mizukami3,
  3. S Tohma4,
  4. T Matsui5
  1. 1Clinical Research Center for Medicine, International University of Health and Welfare
  2. 2Health Evaluation and Promotion Center, Sanno Medical Center, Tokyo
  3. 3Graduate School of Nutritional Science, Sagami Women's University
  4. 4Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Kanagawa
  5. 5Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan

Abstract

Background Dietary and nutritional factors may modulate the onset and/or outcome and comorbidities including cardiovascular diseases in rheumatoid arthritis (RA)[1]. For instance, a potential contribution of sodium intake and the occurrence of autoimmunity has been suggested, however the role of sodium in disease activity of RA is unclear.

Objectives To investigate the potential relationship between dietary intake and current medications and the disease activity of RA.

Methods Patients with RA in outpatient clinic of National Hospital Organization, Sagamihara National Hospital (n=89, M/F=18/71, age 65.0±12.8 yo, mean disease duration 16.8±13.2 y) were enrolled to the study. A questionnaire regarding dietary habit and the brief-type self-administered diet history questionnaire (BDHQ) were used to assess the relationship between clinical activity, status of medication and intake of each foodstuff and nutritional factors. The results were analyzed using IBM SPSS software using Pearson's correlation test and Levene test.

Results The number of current medication was found to weakly correlate with DAS-28 (r=0.386), and negatively with intake of ethanol (r=-0.277). When users of biological disease modulating anti-rheumatic drugs (bDMARDs) were compared with non-users, the biologics-taking patients tended to have higher intake of total energy and carbohydrates than non-users. Use of oral corticosteroids, nor other anti-rheumatic DMARDs, did not significantly impact the total energy or carbo intake in RA patients. Sodium intake did not correlate with the disease status or the number of medications.

Conclusions Although salt intake has been suggested to evoke autoimmunity, the amount of dairy intake of salt does not significantly modulate the current disease activity of RA. Use of biologics, but not of corticosteroids, may lead to increased energy and carbohydrate intake in RA patients.

References

  1. Mizukami Y, et al. Distinct Patterns of Dietary Intake in Different Functional Classes of Patients with Rheumatoid Arthritis. Topics in Clinical Nutrition (in press).

References

Disclosure of Interest None declared

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