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AB0265 The significance of early diagnosis and prognostic evaluation of four kinds of ANTI-CCP antibodies in various types of juvenile idiopathic arthritis
  1. P Zeng1,
  2. H Zeng2
  1. 1Department of Pediatric Allergy, Immunology and Rheumatolog
  2. 2Department of Pediatric Allergy, Immunology and Rheumatology, Guangzhou Women and Children's Medical Center, Guangzhou, China

Abstract

Objectives To investigate the relationship between immunological parameters AKA, anti - CCP, the RF- IGG, RF-IGM and the early diagnosis and prognosis in sub- JIA patients.

Methods Collection of 76 JIA patients in our hospital with system treatment and adhere to the follow-up treatment for at least six months, detect the immunological parameters of AKA, anti- CCP, RF-IGG, RF-IGM in the early diagnosis, compare the Positive rate in different subtypes and prognosis, and make the statistical analysis of sensitivity, specificity and relevant risk, compare to the normal control group of blood of 49 healthy children.

Results There is a significant difference between polyarticular group and normal control group in positive rate of AKA, anti-CCP, RF-IGG, RF-IGM, there is no significant difference between the type of systemic, oligoarticular, enthesitis and the normal control group in autoantibody-positive detection rate. Polyarticular group's sensitivity AKA > anti-CCP, RF-IGG > RF-IGM and four kinds of joint detection, specificity RF-IGM, four kinds of joint detection > AKA > RFIGG > anti-CCP. There is a significantly different between refractory JIA and general JIA patients in AKA positive rate, relative risk OR is 3.514%.

Conclusions The effect of AKA, anti-CCP, RF- IGG, RF-IGM in the different subtypes of JIA about early diagnosis are different, it is found that AKA, anti-CCP has good sensitivity and specificity in polyarticular JIA, AKA appears relate with refractory JIA, it is a large sample of the study to be confirmed that whether it can be a serological marker in the early diagnosis and prognosis of Polyarticular JIA.

Disclosure of Interest None declared

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