Background Rheumatoid arthritis (RA) is a common autoimmune disease of unknown etiology which is characterized by symmetric, chronic inflammatory, peripheral polyarthritis. If it is untreated or unresponsive to therapy, inflammation and joint destruction lead to loss of physical function, inability to carry out daily tasks of living.
In addition to problems related to pain and inflammation, patients with RA are also affected by psychological problems such as anxiety and depression.
It has been a while since, the biologic agents have let RA patients to early remmision, and improved their Quality of life (QOL).
A few studies show relevance between age and QOL among RA patients. Lambert et al. found that age was positively correlated with pain, indicating that increasing age made the situation worse.
Objectives This study aimed to assess the relationship between age and QOL of RA patients who has been treated with biologic agents.
Methods 149 RA patients who treated with biologic agents at Showa University Hospital, Showa University Northern Yokohama Hospital and Showa University Koto Toyosu Hospital were recruited from 2005 to 2016. This study design was retrospective cohort study. Loss to follow-up was eliminated. The patients were divided into two groups, whose age was 65 years old and over (elderly) and under 65 (adults). The primary outcome was the change of QOL in 6months'. QOL was measure using SF-36, and we use physical component scale (PCS) and mental component scale (MCS). Logistic regression analysis was performed.
Results Among 149 RA patients, the mean age was 57 years old and 85.9% was female. 92 out of 149 patients (61.7%) were adult group and 57 (38.3%) were elderly group. Adjusted with sex, disease duration, DAS28-ESR, HAQ, and with or without complications which are interstitial lung disease, diabetes mellitus, and chronic kidney disease, there was no significant difference in change of MCS in 6 months'. But those of PCS was significantly higher in adult's group (regression coefficients -7.25; 95% Confidence Interval (CI) -11.7 to -2.77; p=0.0018).
Conclusions There is a possibility that, younger patient who suffers with RA could achieve better quality of life than those of elderly patients after treatment with biologic agents.
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Disclosure of Interest None declared