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AB0241 Relationship between leptin and disease activity in patients with rheumatoid arthritis
  1. JADJ Batún Garrido1,
  2. IE Juárez Rojop2,
  3. M Salas Magaña2,
  4. Έ Hernández Núñez3,
  5. F Olán3
  1. 1Medicina Interna, Hospital Regional de Alta Especialidad Dr. Gustavo A. Rovirosa Pérez
  2. 2Universidad Juárez Autόnoma de Tabasco
  3. 3Hospital Regional de Alta Especialidad Dr. Gustavo A. Rovirosa Pérez, Villahermosa, Mexico

Abstract

Background Increased concentrations of leptin have been observed during infectious processes and inflammation, in such a way that it plays a role in the inflammatory and the immune response

Objectives Determine the association between serum leptin and disease activity measured through DAS-28 PCR.

Methods Patients with the diagnosis of rheumatoid arthritis (RA) according to the ACR/EULAR 2010 criteria were studied. Leptin was determined by enzyme immunoassay (ELISA) with the TECO® Test Kit, the values higher than 17ng/mL were considered as hyperleptinemia. Disease activity was assessed by the DAS-28 PCR, classifying as remission <2.3, low activity ≥2.3 to <3.8, moderate activity as ≥3.8 to <4.9 and high activity ≥4.9. Statistical analysis was performed using the SPSS 22.0 package. A p≤0.05 was considered a significant result. A multivariate logistic regression model was used to determine the association between significant variables and leptin concentrations.

Results 77 patients were studied, 93,5% were female. The activity of the disease was determined, finding that 40,3% of patients were in remission, 41,6% had low activity, 11,7% had moderate activity and 6,5% had high activity. The 46,8% had obesity, 32,5% were overweight, 18,2% had normal weight and 2,5% were underweight. The 37,7% of the patients studied had metabolic syndrome, being the main factor the presence of an altered abdominal perimeter. The 63,6% had positive rheumatoid factor. The 71,4% had leptin levels ≥17 ng/ml. A multivariate logistic regression was performed with leptin as dependent variable. The results show an independent association between higher concentrations of leptin and disease activity (OR 1,9; 95% CI 1,3–3,8; p=0,045), obesity (OR 3,63; 95% CI 1,1–11,9; p=0,033), the presence of metabolic syndrome (OR 2,74; 95% CI 1,7–10,4; p=0,038), and positive rheumatoid factor (OR 3,5; 95% IC 1,2–11,3; p=0,033). It was also found that at higher disease activity, there were higher concentrations of serum leptin. Patients with severe activity had higher leptin media than patients in remission

Conclusions There is a positive relationship between the activity of the disease and the serum leptin concentration, likewise this hormone is related to other inflammatory processes such as metabolic syndrome and rheumatoid factor.

References

  1. Tilg H, Moschen A. Adipocytokines: Mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol. 2006; 6: 772–83.

  2. Otero M, Lago R, Lago F, Casanueva F, Dieguez C, Gόmez J. Leptin, from fat to inflammation: Old questions and new insights. Febs Lett. 2005; 579: 295–301.

References

Disclosure of Interest None declared

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