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AB0205 Carotid intima-media thickness linked to the presence of cardiovascular risk factors in mexican mestizo patients with rheumatoid arthritis
  1. DA Galarza-Delgado1,
  2. JR Azpiri-Lopez2,
  3. IJ Colunga-Pedraza1,
  4. RE Ramos-Cazares1,
  5. FJ Torres-Quintanilla2,
  6. A Valdovinos-Bañuelos1,
  7. RI Arvizu-Rivera3,
  8. A Martinez-Moreno3,
  9. JA Cardenas-de la Garza3,
  10. JI Garcia-Colunga4,
  11. G Elizondo-Riojas4
  1. 1Rheumatology
  2. 2Cardiology
  3. 3Internal Medicine
  4. 4Radiology and Imaging, Hospital Universitario Dr. José Eleuterio Gonzalez, Monterrey, Mexico

Abstract

Background Rheumatoid Arthritis (RA) is associated to subclinical atherosclerosis. Traditional risk factors for cardiovascular outcomes do not explain completely the higher risk, which could be caused by chronic systemic inflammation.

Objectives The aim of this study is to relate abnormal carotid intima-media thickness (CIMT) to the presence of cardiovascular risk factors.

Methods Observational cross-section design. We included patients who fulfilled the 1987 ACR and/or 2010 ACR/EULAR classification criteria for RA, 40 to 75 years old, with no personal history of atherosclerotic CV disease. A board-certified radiologist performed carotid duplex ultrasounds. Patients were distributed in two groups according to the absence (Group 1) or presence (Group 2) of traditional risk factors for cardiovascular disease (smoking status, dyslipidemia, high blood pressure and diabetes).

Results A total of 82 patients were included. Demographic characteristics for each group are shown in Table 1. Ultrasound findings are shown in Table 2. CIMT alterations were more common in Group 2 (66.7%) than in Group 1 (38.7%), with statistical significance (p=0.013). Presence of carotid plaque was more common in Group 2 (27.5%) than in Group 1 (16.1%), shown clinical relevance, although did not shown statistical significance (p=0.18).

Table 1.

Demographic characteristics

Conclusions In this cohort of Mexican patients with RA, we demonstrate relation between the presence of alterations in CIMT (carotid hypertrophy and carotid plaque) and risk factors for cardiovascular disease, which can be enhanced by intrinsic risk of RA. These findings reaffirm the importance of global health assessment in patients with RA to reduce morbidity.

References

  1. Avina-Zubieta JA. Risk of incident cardiovascular events in patients with rheumatoid arthritis: a meta-analysis of observational studies. Ann Rheum Dis. 2012;71(9):1524–9.

  2. Galarza-Delgado DA, Serna-Pena G. Carotid atherosclerosis in patients with rheumatoid arthritis and rheumatoid nodules. Reumatol Clin. 2013;9(3):136–41.

  3. Mateo I, What measure of carotid wall thickening is the best atherosclerotic loading score in the hypertensive patient: maximum or mean value?]. Rev Esp Cardiol. 2011;64(5):417–20.

References

Disclosure of Interest None declared

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