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OP0134 Long term outcome and prognosis factors of complications in takayasu's arteritis: multicenter study of 318 patients
  1. C Comarmond1,
  2. L Biard2,
  3. M Lambert3,
  4. A Mekinian4,
  5. Y Ferfar1,
  6. J-E Kahn5,
  7. Y Benhamou6,
  8. L Chiche7,
  9. F Koskas7,
  10. P Cluzel8,
  11. E Hachulla3,
  12. E Messas9,
  13. M Resche-Rigon10,
  14. T Mirault9,
  15. P Cacoub1,
  16. D Saadoun1,
  17. on behalf of French Takayasu network
  1. 1Internal Medicine and Clinical Immunology, GROUPE HOSPITALIER PITIΈ-SALPÊTRIÈRE
  2. 2Saint-Louis, Paris
  3. 3Internal Medicine, CHU Lille, Lille
  4. 4Internal Medicine, CHU Saint-Antoine, Paris
  5. 5Internal Medicine, Foch, Suresnes
  6. 6Internal Medicine, CHU Rouen, Rouen
  7. 7Vascular surgery
  8. 8Imagerie CardioVasculaire et de Radiologie Interventionnelle, GROUPE HOSPITALIER PITIΈ-SALPÊTRIÈRE
  9. 9Vascular Medicine, HEGP
  10. 10SBIM, Saint-Louis, Paris, France

Abstract

Objectives To assess long term outcome and to elaborate a prognostic score for vascular complications in patients with Takayasu arteritis (TA).

Methods Retrospective multicenter study of characteristics and outcome of 318 TA patients [86% of females; median age 36 [25–47] years; median follow-up of 6.1 years] fulfilling ACR and/or Ishikawa criteria. Factors associated with the event free survival (EFS), relapse free survival (RFS) and incidence of vascular complications were assessed. A prognostic score for vascular complications was elaborated based on a multivariate model.

Results The 5- and 10-years event free survival (EFS), relapse free survival (RFS) and complication free survival were 48.2% (42.2;54.9) and 36.4% (30.3;43.9), 58.6% (52.7;65.1) and 47.7% (41.2;55.1), and 69.9% (64.3;76) and 53.7% (46.8;61.7), respectively. Progressive disease course (p=0.018) and carotidodynia (p=0.036) were independently associated with EFS. Male gender (p=0.048), elevated C reactive protein level (p=0.013), and carotidodynia (p=0.003) were associated with RFS. Progressive disease course (p=0.017), thoracic aorta involvement (p=0.009), and retinopathy (p=0.002) were associated with complication free survival. We define high risk patients for vascular complications according to the presence of two of the following factors (i.e a progressive clinical course, thoracic aorta involvement and/or retinopathy). The probability of complication free survival at five years was 78.4% (69.4;88.6) and 51.5% (38.3;69.2) in the low risk and high risk group, respectively.

Conclusions This nationwide study shows that 50% of TA patients will relapse and experience a vascular complication at 10 years. We could define high risk TA patients for vascular complications.

Disclosure of Interest None declared

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