Objectives We had to study local and systemic inflammation in rheumatoid arthritis patients with persistence Chlamydia trachomatis (Ch tr) in the joint
Methods 31 patients with early RA; mean age 54,5 (10,6) years, disease duration 21,5 (14,4) weeks witch persistence Ch tr in the joint (mRNP Ch tr had been revealed in synovial fluid by NASBA PCR) were enrolled in this study. The comarison group was patients with RA (n=42) without mRNP in synovial fluid (Ch tr-). Mean age was 51,7 (15,4) years, disease duration 20,8 (13,3) weeks. All the patients had been received only symptomatic treatment (NSAID). Disease activity had been detected by DAS 28. Systemic inflammation was estimated by levels of erythrocyte sedimentation rate (ESR), hsp C-reactive protein (hspCRP), orozomucoid (OR) in the blood samples; local inflammation- by detection hsp CRP, OR in synovial fluid. Also we had been detected level of ACCP in the blood samples and synovial fluid.
Results We didn't reveal statistically significant differences between levels of ESR, hsp CPR, OR, ACCP in blood samples patients with RA Chtr+ and RA Ch tr-. Level of hsp CPR and OR in synovial fluid of research group (Ch tr+) were significantly higher than comparison group (4,1±0,3 mg/l versus 2,4±0,2 mg/l, p<0,05 –hspCRP and 157,4±17,5mg/dl versus 78,5±18,9 mg/dl, p<0,001- OR). In the group of research (Ch tr+) level of ACCP in synovial fluid was statistically significant higher than comparison group (Ch.tr -) (195,6±37,3 versus 67,9±15,4; p<0,001)
Conclusions Patients with early RA detected by NASBA PCR in synovial fluid Ch tr+, had been characterized by absence differences compared RA Ch tr- patients in the level of systemic inflammation and had differences in the level of local inflammation. We revealed high level of ACCP in RA patients with Ch tr in the joints, that may be important for understanding some aspects of RA pathogenesis.
Disclosure of Interest None declared