Objectives To compare power Doppler (PD) vs colour Doppler (CD) semiquantitative and quantitative scoring of synovial vascularization (RA) and to evaluate the relationship between semiquantitative and quantitative scores in patients with rheumatoid arthritis (RA).
Methods One hundred RA patients underwent B-mode, PD, and CD assessments of 12 joints at two European centres. Each joint with synovial hypertrophy detected on B-mode was semiquantitatively scored (0–3) for PD (SPD score) and CD (SCD score) synovial signal. PD and CD synovial signal were also quantitatively scored (0–100%) (QPD and QCD scores, respectively) using a software for counting the colour fraction.
Results We found SH in 184 joints. SPD and SCD agreed in 92.3% (95% CI: 88.4; 96.2%) of paired scores, with Kendall rank correlation coefficient tau-b=0.95. Significant differences between marginal distributions of SPD and SCD were not found (p=0.565). QPD and QCD scores were highly correlated (Pearson's coefficient=0.70) but Blamd-Altman plot showed insufficient agreement, being the QCD scores systematically slightly higher than the QPD scores. The distribution of QPD and QCD values between SPD and SCD scores, respectively, showed significant differences between grade 0 and grade 1 (p<0.001), and grade 2 and grade 3 (p=0.042 and p=0.007, respectively) but not between grade 1 and 2 (p=0.154 and p=0.150, respectively).
Conclusions SPD and SCD scores were concordant and QPD and QCD scores highly correlated although were not concordant. There was consistency between SPD and SCD moderate and severe scores and QPD and QCD scores. There was an overlapping between SPD and SCD mild and moderate scores regarding QPD and QCD scores.
Disclosure of Interest None declared
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