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08.48 Increased body fat but decreased lean body mass and bone mineral density in myositis patients are associated with disease duration, inflammatory status, skeletal muscle involvement and physical activity
  1. Sabina Oreska1,
  2. Maja Spiritovic1,2,*,
  3. Petr Cesak2,
  4. Ondrej Marecek2,
  5. Hana Storkanova1,
  6. Katerina Kubinova1,
  7. Martin Klein1,
  8. Lucie Vernerova1,
  9. Olga Ruzickova1,
  10. Radim Becvar1,
  11. Karel Pavelka1,
  12. Ladislav Senolt1,
  13. Herman Mann1,
  14. Jiri Vencovsky1,
  15. Michal Tomcik1
  1. 1Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
  2. 2Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic
  3. *The authors contributed equally

Abstract

Background Idiopathic inflammatory myopathies (IIM) are characterised by inflammation and atrophy of skeletal muscles, pulmonary and articular involvement, which limit the mobility/self-sufficiency of patients, and can have a negative impact on body composition.

Objectives To assess body composition and physical activity of IIM patients and healthy controls (HC).

Methods 54 patients with IIM (45 females/9 males; mean age 57.3; disease duration 5.8 years; polymyositis (PM,22)/dermatomyositis (DM,25)/necrotizing myopathy (IMNM,7)) and 30 age-/sex-matched HC (25 females/5 males, mean age 54.9) without rheumatic/tumour diseases or manifest cardiovascular event were included. PM/DM patients fulfilled Bohan/Peter criteria for PM/DM. Anthropometric parameters and body composition were assessed (by densitometry-iDXA Lunar, and by bioelectric impedance-BIA2000-M), and physical activity was evaluated using Human Activity Profile (HAP) questionnaire. Routine biochemistry analysis was performed after 8 hours of fasting. Muscle involvement was evaluated by manual muscle test (MMT)−8. Data are presented as mean±SD.

Results Compared to HC, patients with IIM had significantly increased body fat% as assessed by iDXA (BF%: 38.7±6.7 vs. 42.5%±7.1%, p=0.015), but decreased lean body mass as assessed both by iDXA (LBM: 45.7±6.6 vs. 40.3±7.0 kg, p=0.0005) and BIA (LBM: 53.2±8.5 vs. 48.7±9.0 kg, p=0.0295), and increased ECM/BCM ratio (extracellular mass/body cell mass: 1.00±0.12 vs. 1.43±0.42, p<0.0001), which reflects worse muscle predispositions for physical exercise, aerobic fitness/performance, and also increases with deteriorating nutritional status. Compared to HC, IIM patients had significantly lower bone mineral density (BMD: 1.16±0.10 vs. 1.05±0.11 g/cm2, p=0.0010), and were currently able to perform less energetically demanding physical activities according to HAP score (86.3±5.9 vs. 49.0±20.2, p<0.0001). Disease duration negatively correlated with BMD (r=−0.392, p=0.004) and LBM-BIA (r=−0.272, p=0.047). CRP was positively associated with BF% assessed both by DEXA (r=0.276, p=0.035) and BIA (r=0.306, p=0.025). MMT-8 score negatively correlated with ECM/BCM ratio (r=−0.385, p=0.006), and physical activity (HAP) negatively correlated with BF%-DEXA (r=−0.292, p=0.032).

Conclusions Compared to healthy age-/sex-matched individuals we found significant negative changes in body composition of our IIM patients, which are associated with their disease duration, inflammatory status, skeletal muscle involvement, and physical activity, and could reflect their impaired nutritional status and predispositions for physical exercise, aerobic fitness and performance.

Acknowledgement Supported by AZV-16–33574A.

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