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AB0236 The Role of Vitamin D Receptor in Rheumatoid Arthritis
  1. P. Nemec1,
  2. M. Sefcik2,
  3. J. Sevcikova2,
  4. L. Prochazkova1,
  5. M. Pavkova-Godbergova2
  1. 12nd. Dept. of Internal Medicine, St. Anne's Faculty Hospital Brno and Faculty of Medicine, Masaryk University
  2. 2Department of Pathological Physiology, Masaryk University, Brno, Brno, Czech Republic

Abstract

Background Rheumatoid arthritis (RA) is a disease characterized by chronic inflammation of synovial tissue, and progressive destruction of the joints. In RA patients a high prevalence of serum vitamin D deficiency/insufficiency was described. Vitamin D has a central role in the immune system and also correlates with increased levels of estrogen receptor α.

Objectives The study analyzed the relationships between polymorphisms in the gene for vitamin D receptor (VDR) and the development and/or progression of the disease.

Methods A total of 156 patients were enrolled with a diagnosis of RA (median age 55.6 years; 78% of them women; control group of 50 subjects). Development of the disease was scored by positive antibodies against cyclic citrullinated peptide (anti-CCP), rheumatoid factor (RF), CRP. Disease progression was assessed by the modified Sharp-van der Heijdeovou method Total Sharp Score (TSS). Polymorphisms were detected by PCR and subsequent restriction analysis (rs4516035 EcoRV; rs7975232: ApaI; rs731236: TaqI).

Results The results show the relation of polymorphism VDR rs4516035 to seropositivity for anti-CCP in the distribution of genotypes (P=0.03), with a higher prevalence of the TT genotype when compared to the CC + CT variants (p=0.007, OR =3.2). The relationship was found also in the frequency of alleles (p=0.04). Further, a borderline relationship of this polymorphism to RF IgA levels (P=0.06) was detected. A relationship of polymorphism VDR rs731236 with the disease progression evaluated by TSS (p=0.02) was demonstrated, with the highest TSS in the patients carrying the GG variant.

Conclusions The results show that the GG variant of VDR rs731236 polymorphism was associated with a worse prognosis of RA. Moreover, the VDR rs4516035 polymorphism was related to the seropositivity for anti-CCP, with a significant prevalence of TT genotype in positive RA patients.

Disclosure of Interest None declared

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