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AB0065 Galectin-3 Is A Major Determinant of Femoral Neck Bone Mineral Density in A Partial Regression Model: A Preliminary Study
  1. C. Ko,
  2. Y.-J. Su
  1. Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, Province of China

Abstract

Background Low bone mass is an essential extra-articular feature of rheumatoid arthritis (RA). Patients with RA might present an increased risk of low bone mass as a result of systemic inflammation by alteration of the RANK/RANKL/osteoprotegerin and Wnt/ catenin pathways. In RA, serum galectin-3 correlated with C-reactive protein levels and was considered as biomarker of inflammation. However, recent studies showed abundant galectin-3 observed in the area of severe bone destruction may act as a negative regulator for the upregulated osteoclastogenesis. The role of Galectin-3 is unclear in the regulation of bone resorption in RA.

Objectives The objectives of our study were to evaluate bone mineral density (BMD) and the levels of Galactin-3 and Dkk-1 in RA patients and to study the relation between these parameters.

Methods Patients with active RA were checked with galactin-3, Dkk-1 and followed up with BMD assessment and inflammatory evaluation by ultrasonography (US). Serum galectin-3, Dkk-1 concentrations were assayed with ELISA assay. BMD was measured at hip neck by a Dual-energy X-ray absorptiometry (DXA) (Explorer; Hologic Inc., USA). Grey scale and Power doppler US were graded using a 4-grade semiquantitative scoring system, on a scale of 0–3 at wrist. Each wrist was scanned from lateral to medial aspects in longitudinal planes Radius-Lunate-capitate (volar and dorsal), dorsal Radius-scaphoid-trapezoid, and dorsal Ulna-triquetral. Demographic and clinical data, DAS-28, and erythrocyte sedimentation rate (ESR) were recorded for each patient. Correlations between variables and multilinear regression analysis were performed to check serum galectin-3 expression levels and BMD parameters.

Results (1) Six RA patients 50% were female, age was 57.3±4.4 years, disease duration was 6.9±3.8 years and disease activity DAS 28 was 6.33±0.31. (2) The galectin-3, Sonography inflammatory score and serum iPTH levels showed a significant negative association with BMD at the hip.(Table.1) (3) The multilinear regression analysis showed iPTH, Galactin3 and US score were found to explain 99% of the variance in BMD in hip neck.(4) However, the galectin-3 in multilinear regression analysis showed a positive association with BMD at the hip. (correlation coefficient=0.126, p value=0.014) (Table.2)

Table 1.

Characteristics of patient and Variables that correlated with hip neck bone mineral density (BMD)

Table 2.

Final step in multilinear regression analysis with backward elimination

Conclusions Galectin-3 is a major determinant of femoral neck BMD in this partial regression model, after controlling iPTH and sonography inflammatory score, in our preliminary study.

  1. Diarra, Danielle, et al. Nature medicine 13.2 (2007): 156–163.

  2. Ohshima, Shiro, et al. Arthritis & Rheumatism 48.10 (2003): 2788–2795.

  3. Li, Yin-Ji, et al. Laboratory Investigation 89.1 (2009): 26–37.

Disclosure of Interest None declared

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