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AB0031 Evaluation of Serum Fetuin-A and Apelin Levels in Familial Mediterranean Fever (FMF) Patients and Healthy Subjects
  1. A. Şahin1,
  2. Ö. Demirpençe2,
  3. M. Şahin2,
  4. D. Seven3,
  5. H.O. Doğan2,
  6. A. Camcı1
  1. 1Rheumatology - Internal Medicine
  2. 2Biochemistry
  3. 3Internal Medicine, Cumhuriyet University Medical Faculty, Sivas, Turkey


Background Apelin is an adipokine that its level is increased by some proinflammatory cytokine such as TNF-alpha in metabolic, autoimmune and inflammatory conditions (1). Fetuin-A is protein secreted by liver, kidney, bone, brain, lungs and cardiovascular system (2). The levels of fetuin-a are decreased in some rheumatic diseases (ie. Rheumatoid arthritis, osteoarthritis). It has been suggested that fetuin-a can be a novel inflammatory biomarker in familial Mediterranean fever (FMF) (3).

Objectives To evaluate of the serum Apelin, Fetuin-A levels in patients with FMF during attack-free period (AFP) and to compare with healthy subjects.

Methods Thirty-FMF patients with AFP and thirty healthy subjects were included this study. The erythrocyte sedimentation rate (ESR), CRP, fibrinogen, hemogram, Mediterranean fever (MEFV) gene profiles, BMI, insulin, HOMA-IR, lipid profiles, serum apelin, fetuin-a levels were investigated.

Results Of the FMF patients and control, 20 (66.7%) was female and 10 (33.3%) was male. The distribution of MEFV gene mutation frequencies in the FMF patients was no mutation in 4 (13.3%) patients, M694V heterozygous in 7 (23.3%), M694V homozygous in 3 (10%), E148Q heterozygous in 5 (16.7%), M680I heterozygous in 2 (6.7%), M680I homozygous in 1 (3.3%), V726A in 2 (6.7%) and compound heterozygous mutation in 6 (20%). The median levels of apelin were 307.82±52.76 ng/mL in healthy subjects and 113,07±15,9 ng/mL in FMF (p=0.002) (Figure 1). The median levels of fetuin-a were 843,82±137.66 ng/mL in control group and 1352.2±127.61 ng/mL in FMF group (p=0.009) (Figure 1).

Conclusions The lower serum apelin and higher fetuin-a levels in FMF patients with AFP than in healthy subjects were observed. It may be suggested that subclinical vascular inflammation is continued during attack-free period in patients with FMF.

  1. Andrade-Oliveira V, Camara NO, Moraes-Vieira PM. Adipokines as drug targets in diabetes and underlying disturbances. J Diabetes Res 2015;2015:681612. doi: 10.1155/2015/681612. Epub 2015 Apr 8.

  2. Xiao J, Wang XR, Hu KZ, et al. Serum fetuin-A levels are inversely associated with clinical severity in patients with primary knee osteoarthritis. Biomarkers 2013 Feb;18(1):51–4. doi: 10.3109/1354750X.2012.730551. Epub 2012 Oct 16.

  3. Oncu K, Yazgan Y, Tanoglu A, et al. Can serum fetuin-A be regarded as an inflammatory marker among patients with familial Mediterranean fever? Dig Dis Sci 2013 Nov;58(11):3212–7. doi: 10.1007/s10620-013-2814-7. Epub 2013 Aug 8.

Acknowledgement We would like to thank to Ahmet Altun, M.D. for his statistical analysis.

Disclosure of Interest None declared

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