Background The number of osteoarthritis (OA) patients is increasing year by year because of the aging society. Especially, knee OA is reported to reduce the health life expectancy. The majority of patients are at the early stage of knee OA and are adapted to conservative treatments such as exercise therapy. A lot of biomarkers for cartilage metabolism were previously reported. However, there are few reports that exercise therapy has an effect on the biomarkers related for cartilage metabolism.
Objectives To investigate the effect of an exercise therapy on cartilage metabolism using biomarkers.
Methods Thirty-eight females (mean age: 59 years) participated in this study. All participants started a weekly exercise and continued it for twelve weeks. Before and after the exercise program, we measured their physical activities; Timed Up and Go test (TUG) and Three Minutes Walking test (3MW). Since the program started, we have collected serum and urine samples from the participants at the start of the program (0 week), at the end of it (12 weeks) and 12 weeks after it (24 weeks). For the collected samples, we measured the following two anabolic and one catabolic biomarkers; serum cartilage type II procollagen carboxy propeptide (sPIICP), serum cartilage oligomeric matrix protein (sCOMP), urine C-terminal telopeptide of collagen type II (uCTX-II). These biomarkers were measured with the enzyme-linked immunosorbent assay method.
Results After the twelve weeks exercise program, both TUG and 3MW were significantly improved (P <0.01 each, respectively) (Fig. A, B). sCOMP concentrations at 12 weeks were relatively greater than those at 0 week. However, sCOMP concentrations at 24 weeks were significantly greater than those at 12 weeks (P <0.01) (Fig. C). In contrast, uCTX-II concentrations at 24 weeks were significantly less than those at 0 week (P <0.01) (Fig. D). There was no significant difference between pre- and post-excise sPIICP concentrations.
Conclusions These results suggest that an exercise therapy will improve physical activities and that this therapy could influence both cartilage anabolic and catabolic biomarkers.
Disclosure of Interest None declared