Background Autoimmune conditions often reflect dysregulation of the immune system, which appears to be of great significance in the development of malignancies . Previous studies support an association between systemic lupus erythematosus (SLE) and malignancies; however, their findings on specific malignancies are inconsistent, and their design might not represent the population of SLE patients, due to selection bias [2–4].
Objectives Our goal was to investigate the association between the presence of SLE and various malignancies, in a large-scale population-based study.
Methods Data for this study was collected from the database of “Clalit Health services”, the largest state-mandated health service organization in Israel. All adult members diagnosed with SLE were included (n=5,018) and their age and sex-matched controls (n=25,090), creating a cross-sectional population-based study. Medical records of all subjects were analyzed for documentation of malignancies. Logistic regression was preformed to control for age, gender, BMI, smoking and socioeconomic status.
Results Diagnosis of malignancy (of any type) was more prevalent in the SLE population in comparison to controls (odds ratio [OR] 3.35, 95% confidence interval [CI] 3.02–3.72). Also, SLE diagnosis was found to be independently associated with higher proportions of non-Hodgkin lymphoma (OR 3.02, 95% CI 2.72–3.33), Hodgkin lymphoma (OR 2.43 95% CI 1.88–2.99), multiple myeloma (OR 2.57, 95% CI 1.85–3.28), cervix uteri malignancies (OR 1.65, 95% CI 1.10–2.20) and genital organ malignancies (OR 2.32 95% CI 1.42–3.22), after adjustment for confounding variables.
Conclusions SLE diagnosis was found to be independently associated with higher proportions of malignancies, specifically hematologic malignancies. These findings should be considered when treating SLE patients, and possibly influence their screening routine.
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Disclosure of Interest None declared
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