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SAT0403 Treatment with Golimumab or Infliximab Reduces Health Resource Utilization and Increases Work Productivity in Patients with Ankylosing Spondylitis in The QUO-VADIS Study, A Large, Prospective Real-Life Cohort
  1. P. Sarzi-Puttini1,
  2. F. Van Den Bosch2,
  3. P. Claudepierre3,
  4. S. Sajjan4,
  5. N. Vastesaeger5,
  6. M. Govoni6,
  7. S. Kachroo4
  1. 1UOC Reumatologia, Ospedale L. Sacco Polo Universitario, Milano, Italy
  2. 2Ghent University Hospital, Ghent, Belgium
  3. 3Université Paris Est Créteil, Créteil, France
  4. 4Merck Sharp & Dohme, Kenilworth, United States
  5. 5Merck Sharp & Dohme, Brussels, Belgium
  6. 6Merck Sharp & Dohme, Rome, Italy


Background The true cost of treating Ankylosing Spondylitis (AS) comprises several elements including not only medication, but also healthcare resource utilization (HCRU), reduced work productivity, and absenteeism.

Objectives We report the results from the QUality of Life as Outcomes and its VAriation with DIsease States (QUO-VADIS) study on the effect of the anti-tumor necrosis factor (TNF) agents, golimumab (GLM) and infliximab (IFX), on HCRU for patients with AS as well as their ability to work.

Methods This was a prospective observational study in bionaïve AS patients (modified New York criteria) newly treated with GLM or IFX (originator) in a clinical practice setting. Patients were followed-up for ∼6 months of treatment with GLM or IFX and data was collected at baseline (BL), and at 3 and 6 months. The assessment of HCRU was done by evaluating data on the use of concomitant medications, hospitalizations (inpatient care or acute care) and visits in day care and outpatient settings; HCRU data reflected the prior 3 months for each timepoint. Work productivity and activity impairment (WPAI) was assessed by the number of work days missed as well as quantifying absenteeism, presenteeism, work impairment, and activity using the WPAI instrument adapted to Spondylarthritis (WPAI-SpA)(1); WPAI was based on the 7 days prior to the administration of the questionnaire.

Results 963 patients received ≥1 dose of medication. The vast majority (78%, n=751) was treated with GLM, while the rest (22%, n=221) received IFX. Mean age of the patients was 42.7 years, 61.4% were male. Concomitant medication usage for AS treatment was reported by 84.3% of patients, the vast majority of whom received NSAIDs, followed by analgesics, DMARDs and corticosteroids. At BL, the percent of patients who reported hospitalizations (inpatient care) in the prior 3 months was 13.6%, which decreased to 3.1% at 6 months, while outpatient care in the 3 months prior to BL was reported by 39.4% of patients, which decreased to 19.0% at 6 months. The percent of patients receiving acute emergency care in the 3 months prior to BL reduced from 1.6%0.3% at 6 months. Further details on HCRU at BL and at 6 months are shown in the Table. The mean (SD) number of days at work, missed due to AS, was reduced from 6.3 (31.1) days at BL to 2.7 (12.3) days at 6 months. Results for WPAI-SpA assessment are presented in the Table.

Conclusions In patients with AS newly treated with GLM (almost 80% of the study population) or IFX for 6 months, HCRU was reduced, as shown by the shorter mean duration of hospitalizations and the proportion of patients receiving acute, inpatient or outpatient care. Additionally, work productivity and activity increased, and patients reported fewer days of work missed due to AS after 6 months of treatment.

  1. Tang et al. Arthritis Care Res 2011; 63: S337–349

Disclosure of Interest P. Sarzi-Puttini: None declared, F. Van Den Bosch Consultant for: Merck & Co., Inc.; Abbvie; Novartis; Pfizer; UCB; Bristol Myers Squibb, Celgene, Janssen, P. Claudepierre: None declared, S. Sajjan Employee of: Merck Sharp & Dohme, N. Vastesaeger Employee of: Merck Sharp & Dohme, M. Govoni Employee of: Merck Sharp & Dohme, S. Kachroo Employee of: Merck Sharp & Dohme

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