Article Text

PDF
SAT0356 Experience in The Use of 18F-FDG PET/CT in Patients with Polymyalgia Rheumatica in HUP la Fe
  1. K. Arévalo Ruales1,
  2. R. Negueroles Albuixech1,
  3. J.L. Loaiza Gόngora2,
  4. P. Sopena Novales2,
  5. E. Grau Garcia1,
  6. I. Martínez Cordellat1,
  7. J. Valero Sanz1,
  8. J. Ivorra Cortés1,
  9. L. González Puig1,
  10. I. Chalmeta Verdejo1,
  11. C. Feced Olmos1,
  12. E. Labrador Sánchez1,
  13. F.M. Ortiz Sanjuan1,
  14. J. Fragio Gil1,
  15. C. Alcañiz Escandell1,
  16. G. Poveda Marín1,
  17. C. Nájera Herranz1,
  18. V. Fornes Ferrer3,
  19. J. Román Ivorra1
  1. 1Rheumatology Department
  2. 2Nuclear Medicine Department, HUP la Fe
  3. 3Biostatistics Unit, IIS la Fe, Valencia, Spain

Abstract

Background Polymyalgia rheumatica (PMR) is an inflammatory disease characterized by pain and stiffness that usually affects the upper body and the pelvis. PMR is related frequently to another inflammatory disorder called giant cell arteritis (GCA), where about 50% of patients present polymyalgia. PET/CT offers functional and molecular information about inflammatory diseases that leads to the vasculitis diagnosis in an early stage, so PET/CT is a useful diagnosis tool to identify CGA associated with PMR

Objectives To evaluate the incidence of GCA in patients diagnosed of PMR.

Methods Prospective study from January 2011 until December 2015 including patients with PMR from the Rheumatology Department of HUP La Fe. In all cases to confirm the diagnosis of vasculitides an 18-FDG PET/CT was made. Also blood analysis that includes CRP and ERS, US and biopsy and treatment with esteroids or another DMARD was done. Statistical analysis was performed using R software 3.2.3.

Results 23 patients with PMR diagnosis according to established Bird/Wood criteria were included, with a mean age at the time of PET/CT of 69.3 years (38–85). 18 were treated with steroids before PET/CT and 11 had another DMAR during follow up.

In 47.8% of patients vasculitis was detected using PET/CT. Most frequent injury locations were aorta, iliac artery, and femoral artery. In these patients there is an increase in the CRP value (P=0.03) comparing to those without vasculitides. There were no significant differences in the ESR value or in the DMAR administration.

Conclusions PET/CT is a useful diagnostic tool for the early diagnosis of vasculitides associated with PMR. This allows an early and adequate treatment in order to avoid structural damages within the blood vessel (aneurysms, stenosis, oclussions), reducing morbi-mortality and fatal outcomes.

Disclosure of Interest None declared

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.