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SAT0320 Igg3 Autoantibodies Binding To Stathmin-4 as Marker of Polyneuropathy in Primary Sjögren Syndrome
  1. S. Ross,
  2. T. Witte,
  3. M. Stangel,
  4. R.E. Schmidt,
  5. N.T. Baerlecken
  1. Department of Clinical Immunology and Rheumatology, Medical University Hannover, Hannover, Germany

Abstract

Background Primary Sjögren-syndrome (pSS) is considered as autoimmune phenomena affecting exocrine glands with various clinical phenotyps. PSS can appear with different extraglandular manifestations such as arthritis, myositis, vasculitis and peripheral or central neuropathies. 8.5–67% of patients with pSS complain about neurological symptoms. About 9% can be diagnosed having a destinct form of polyneuropathy (PNP).

Objectives Here, we investigated autoantibodies binding to stathmin-4 (STMN-4) in pSS with PNP.

Methods We screened 4 versus 4 having pSS with and without PNP for discriminating autoantibodies by using protein array technology. We identified autoantibodies binding to STMN-4 in patients with pSS and PNP. We evaluated our finding by establishing different ELISA detections for STMN-4 autoantibodies using sera of different underlying diseases (n=484).

Results Using Anti-IgG3 STMN-4, we tested the following groups. In pSS with PNP 33% had anti-IgG3 STMN-4 antibodies and 6% without PNP had anti-IgG3 STMN-4 (likelihood 5.5).

Anti-IgG3 STMN is associated with PNP in pSS patiens (Fisher exact two-tailed p-value=0.016). We could not see any significant association in other diseases with PNP and metabolic or toxic induced PNP.

Conclusions Anti-IgG3 STMN is a new potential marker for PNP in patients with pSS.

  1. none

Disclosure of Interest S. Ross Shareholder of: none, Grant/research support from: none, Consultant for: none, Employee of: none, Paid instructor for: none, Speakers bureau: none, T. Witte Shareholder of: none, Grant/research support from: none, Consultant for: none, Employee of: none, Paid instructor for: none, Speakers bureau: none, M. Stangel Shareholder of: none, Grant/research support from: none, Consultant for: none, Employee of: none, Paid instructor for: none, Speakers bureau: none, R. Schmidt Shareholder of: none, Grant/research support from: none, Consultant for: none, Employee of: none, Paid instructor for: none, Speakers bureau: none, N. Baerlecken Shareholder of: none, Grant/research support from: none, Consultant for: none, Employee of: none, Paid instructor for: none, Speakers bureau: none

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