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SAT0282 Frequency and Predictors of Attainment of The Lupus Low Disease Activity State (LLDAS) in A Cross Sectional Study of Sle Patients in The Asia Pacific
  1. V. Golder1,
  2. R. Kandane-Rathnayake1,
  3. A. Hoi1,
  4. W. Louthrenoo2,
  5. Y. An3,
  6. Z.G. Li4,
  7. S.F. Luo5,
  8. S. Sockalingam6,
  9. C.S. Lau7,
  10. A.L. Lee7,
  11. M.Y.T. Mok7,
  12. A. Lateef8,
  13. K. Franklyn1,
  14. S.V. Navarra9,
  15. L. Zamora9,
  16. Y.-J. Wu10,
  17. L. Hamijoyo11,
  18. M. Chan12,
  19. S. O'Neill13,
  20. F. Goldblatt14,
  21. M. Huq15,
  22. M. Nikpour15,
  23. E.F. Morand1,
  24. on behalf of Asia-Pacific Lupus Collaboration
  1. 1Rheumatology, Monash University, Melbourne, Australia
  2. 2Chang Mai University, Chang Mai, Thailand
  3. 3Rheumatology, Peking University Health Science Center
  4. 4Rheumatology, Peking University Health Science Centre, Beijing, China
  5. 5Rheumatology, Chan Gung University, Taipei, Taiwan, Province of China
  6. 6Medicine, University of Malaya, Kuala Lumpur, Malaysia
  7. 7Hong Kong University, Hong Kong, Hong Kong
  8. 8National University Hospital, Singapore, Singapore
  9. 9University of Santo Tomas Hospital, Manila, Philippines
  10. 10Chang Gung University, Taipei, Taiwan, Province of China
  11. 11Hasan Sadikin Hospital, Bandung, Indonesia
  12. 12Tan Tock Seng Hospital, Singapore, Singapore
  13. 13University of New South Wales, Sydney
  14. 14Repatriation General Hospital, Adelaide
  15. 15University of Melbourne, Melbourne, Australia

Abstract

Background Systemic lupus erythematosus (SLE) is a heterogeneous disease characterised by fluctuating disease activity. A low disease activity endpoint, the Lupus Low Disease Activity State (LLDAS), was recently reported and retrospective validation showed that time spent in LLDAS translated into reduced damage accrual (Franklyn, Ann Rheum Dis, 2015). A large prospective study to validate LLDAS in a multiethnic cohort of lupus patients from the Asia Pacific Region is underway.

Objectives To describe the frequency and identify the predictors of fulfilling criteria for LLDAS in baseline visit data from a large multinational multiethnic cohort of patients with SLE in nine Asia Pacific countries.

Methods Prospectively collected baseline visit data from 1846 SLE patients enrolled in a longitudinal study were analysed cross sectionally against the recently published definition of LLDAS, and patient characteristics associated with LLDAS attainment determined.

Results LLDAS criteria were met by 44% of patients at a single baseline visit. Stepwise multivariable logistic regression revealed that patients with shorter disease duration were less likely to be in LLDAS (OR 0.31, 95% CI 0.19–0.49, p<0.001). Likewise, discoid rash (OR 0.66, 95% CI 0.49–0.89, p=0.006), renal disease (OR 0.60, 95% CI 0.48–0.75, p<0.001), elevated double stranded DNA (OR 0.65, 95% CI 0.53–0.81, p<0.001) or hypocomplementaemia (OR 0.52, 95% CI 0.40–0.67, p<0.001) were negatively associated with LLDAS attainment. Significant differences in LLDAS attainment between countries were observed, and higher national social wealth as measured by the Gross Domestic Product per capita was positively associated with LLDAS (OR 1.57, 95% CI 1.25–1.98, p<0.001).

Conclusions Low disease activity was observed in less than half of SLE patients at a single point in time. Disease duration and phenotype, as well as national social wealth, were predictive of LLDAS attainment.

Disclosure of Interest None declared

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