Background In a previous study it has been shown shown that, in patients with systemic sclerosis (SSc), the cumulative number of micro-haemorrhages (MH) and micro-thrombosis (MT), computed in eight finger nailfold videocapillaroscopy (NVC), and called NEMO score, was strongly predictive of disease activity (DA) measured by means of European Scleroderma Study Group (ESSG) score. Even the number of giant capillaries (GC) was correlated to a lesser extent with the ESSG score, and then a modified (m) NEMO score was proposed in which the combined presence of a MH/MT and GC was considered .
Objectives The present study was aimed at validating NEMO score in different cohorts of patients.
Methods NEMO score and the total number of GC were assessed by eight finger NVC in 122 patients with SSc referring to the Rheumatic Disease Unit of the “Istituto G.Pini” of Milan, where the preliminary study had been carried out (internal validation). The same procedure was performed in 99 patients collected in a different centre, i.e., the Rheumatic Dept. of the II University of Naples (external validation). In all of the patients DA, measured by ESSG score, was assessed at the same time of NVC performance.
The mNEMO score does not add anything in terms of sensitivity and specificity to the performance of the simple NEMO score in predicting DA.
Conclusions This validation study confirms that the presence of a certain number of MH plus that of MT in eight finger NVC may represent a simple screening method to predict the presence of DA in patients with SSc.
Sambataro D, et al. Arthritis Res & Ther 2014;16:462.
Disclosure of Interest None declared