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SAT0209 Idiopathic Inflammatory Myopathies: Evaluation of Skeletal Muscle Glucose Metabolism by PET-CT 18F-FDG
  1. J. Matuszak,
  2. A. Meyer,
  3. I.-J. Namer,
  4. B. Geny,
  5. J. Sibilia,
  6. C. Blondet
  1. Hôpitaux Universitaires, Strasbourg, France

Abstract

Background There is a need for tools to measure muscle disease activity in inflammatory myopathies (IM).

Objectives To assess the contribution of metabolic imaging with positron emission tomography combined with computed tomography (PET-CT) 18F fluorodeoxyglucose-(18F-FDG) for muscle disease activity assessment in patients with IM.

Methods The SMGM was higher in IM than in the control group in visual analysis (p<0.001) and quantitative analysis (p<0.001). No correlation was found between the SMGM and the muscle histological findings. In addition, the quantitative measurement of SMGM was significantly correlated with serum CK levels (Spearman ρ=0.47, p<0.01) and with the MITAX (Spearman ρ=0.72; p=0.001). Finally, in 9 patients who underwent two consecutive 18F-FDG PET-CT, the evolution of the SMGM was concordant with the clinical course according to the MITAX in 8.

Results The SMGM was higher in IM than in the control group in visual analysis (p<0.001) and quantitative analysis (p<0.001). No correlation was found between the SMGM and the muscle histological findings. In addition, the quantitative measurement of SMGM was significantly correlated with serum CK levels (Spearman ρ=0.47, p<0.01) and with the MITAX (Spearman ρ=0.72; p=0.001). Finally, in 9 patients who underwent two consecutive 18F-FDG PET-CT, the evolution of the SMGM was concordant with the clinical course according to the MITAX in 8.

Conclusions These data suggested that 18F-FDG PET-CT, which is useful for the screening of cancer associated IM, is also helpful for the measurement of IM muscle disease activity.

Disclosure of Interest None declared

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