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SAT0016 Role of PCR, GCKR, HNF1A, LEPR, ASCL1 and NLRP3 in Atherosclerosis in Patients with Rheumatoid Arthritis
  1. R. Lopez-Mejías1,
  2. F. Genre1,
  3. S. Remuzgo-Martínez1,
  4. M. Robustillo-Villarino2,
  5. B. Ubilla1,
  6. J. Llorca3,
  7. V. Mijares1,
  8. A. Corrales1,
  9. C. González-Juanatey4,
  10. J.A. Miranda-Filloy5,
  11. T. Pina1,
  12. R. Blanco1,
  13. E. Vicente6,
  14. J.J. Alegre-Sancho2,
  15. C. Magro7,
  16. E. Raya7,
  17. B. Tejera-Segura8,
  18. M.A. Ramírez Huaranga9,
  19. C. Gόmez-Vaquero10,
  20. A. Balsa11,
  21. D. Pascual-Salcedo11,
  22. F.J. Lόpez-Longo12,
  23. P. Carreira13,
  24. I. González-Άlvaro6,
  25. L. Rodríguez-Rodríguez14,
  26. B. Fernández-Gutiérrez14,
  27. I. Ferraz-Amaro8,
  28. S. Castañeda6,
  29. J. Martín15,
  30. M.A. González-Gay1,16,17
  1. 1Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Department, IDIVAL, Santander
  2. 2Rheumatology Department, Hospital Universitario Doctor Peset, Valencia
  3. 3Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander
  4. 4Cardiology Department, Hospital Lucus Augusti
  5. 5Division of Rheumatology, Hospital Universitario Lucus Augusti, Lugo
  6. 6Rheumatology Department, Hospital Universitario la Princesa, IIS-Princesa, Madrid
  7. 7Rheumatology Department, Hospital Clínico San Cecilio, Granada
  8. 8Rheumatology Division, Hospital Universitario de Canarias, Santa Cruz de Tenerife
  9. 9Rheumatology Department, Hospital General Universitario de Ciudad Real, Ciudad Real
  10. 10Department of Rheumatology, Hospital Universitario Bellvitge, Barcelona
  11. 11Department of Rheumatology, Hospital Universitario La Paz
  12. 12Department of Rheumatology, Hospital General Universitario Gregorio Marañόn
  13. 13Department of Rheumatology, Hospital Universitario 12 de Octubre
  14. 14Department of Rheumatology, Hospital Clínico San Carlos, Madrid
  15. 15Institute of Parasitology and Biomedicine Lόpez-Neyra, IPBLN-CSIC, Granada, Spain
  16. 16Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
  17. 17School of Medicine, University of Cantabria, Santander, Spain

Abstract

Background Rheumatoid arthritis (RA) is an autoimmune inflammatory disease associated with accelerated atherosclerosis and increased cardiovascular (CV) disease. Elevated levels of the C-reactive protein (CRP) are related to an increase risk of coronary artery disease [1] and stroke [2]. Recently, PCR, GCKR, HNF1A, LEPR, ASCL1 and NLRP3 have been associated with CRP levels in non-rheumatic population [2].

Objectives We aimed to determine the potential role of these genes in the development of CV disease and subclinical atherosclerosis in patients with RA.

Methods Genotyping was performed in 2,384 Spanish RA patients by TaqMan assays. Subclinical atherosclerosis was determined by carotid ultrasonography (US) in 1,193 patients.

Results No statistically significant differences were found when PCR, GCKR, HNF1A, LEPR, ASCL1 and NLRP3 were assessed according to the presence/absence of CV disease. It was also the case when patients were stratified according the presence/absence of subclinical atherosclerosis.

Conclusions Our results do not confirm an association between these genes and the development of CV disease and subclinical atherosclerosis in patients with RA.

  1. Danesh et al. N Engl J Med 2004, 350(14):1387–1397;

  2. Ridker et al. N Engl J Med 1997, 336(14):973–979;

  3. Dehghan A et al. Circulation, 123(7):731–738.

Acknowledgement This study was supported by European Union FEDER funds and “Fondo de Investigaciόn Sanitaria” (grants PI12/00060 and PI15/00525) from `Instituto de Salud Carlos III” (ISCIII, Health Ministry, Spain). It was also partially supported by RETICS Programs RD12/0009 (RIER) from “Instituto de Salud Carlos III” (ISCIII, Health Ministry, Spain), and in part by grants from the European IMI BTCure Program. RL-M and BU is supported by funds from the RETICS Program (RIER) (RD12/0009/0013). FG is a recipient of a Sara Borrell postdoctoral fellowship from the “Instituto Carlos III de Salud” at the Spanish Ministry of Health (Spain) (CD15/00095).

Disclosure of Interest None declared

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