Background FMF is an inherited autoinflammatory disease characterized by recurrent episodes of fever, acute serosal inflammation and pain. The QoL and mental health of FMF patients may be affected due to life-long disease, attack frequency, resistance of the disease, and severe complications such as amyloidosis.
Objectives In this study, we investigated the effect of attack frequency on QoL and mental health (MH) in FMF patients.
Methods A total of 149 patients (79 F, 70 M) diagnosed with FMF in Ankara Numune Education and Research Hospital Rheumatology Clinic, and 100 healthy controls (HC) (54 F, 46 M) were included in the study. Patients diagnosed with FMF according to Tel-Hashomer criteria. Mean±SD age of FMF patients is 36±10 year, and mean±SD age of HC is 35±8 year, NS. Mean±SD at onset of FMF patients is 17±4 year, and mean±SD age of disease duration is 107±71 months. FMF patients were classified as the ones that had >2, 1–2, and no attacks in the previous 3 months. The QoL was determined with SF-36, and MH was analyzed with Hospital Anxiety and Depression Scale (HADS). Student t test was used to compare FMF and HC groups for HADS-Anxiety (HADS-A) and HADS-Depression (HADS-D) scores, and physical component summary scores (PCSS), mental component summary scores (MCSS), and subscale scores of SF-36. One Way Anova was used to analyze FMF patients for HADS-A and HADS-D, and PCSS and MCSS of SF-36 in relation with attack frequency. The associations of age, gender, SF-36 and HADS scores in both groups, and comparisons of SF-36 and HADS scores in relation with age at diagnosis and duration of disease in FMF patients were analyzed with Pearson's correlation. p<0.05 was regarded as significant.
Results The summary scores of SF-36, and HADS-A and HADS-D of FMF patients and HC are presented in Tables 1. SF-36 summary scores, and HADS scores of FMF patients in relation with attack frequency, and SF-36 subscale scores of FMF patients and HC are presented in Table 2 and Figure 1. There were no significant correlations among age and gender, and QoL and mental health scores in either group. PCSS and MCSS of SF-36 were significantly lower, and HADS-A and HADS-D scores were significantly higher in FMF patients compared to HC (p<0.001). In addition, attack frequency showed negative correlations with PCSS and MCSS, and positive correlations with HADS-A and HADS-D in FMF patients (p<0.001). PCSS and MCSS showed negative correlations with HADS-A and HADS-D in FMF patients (p<0.001). Age at diagnosis and duration of disease were not correlated with QoL or MH scores.
Conclusions In this study, we found lower QoL scores, and higher anxiety and depression scores in FMF patients compared to HC. Attack frequency determined this effect independent of age and gender.
Disclosure of Interest None declared