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FRI0479 Efficacy of Colchicine and IL-1 Inhibitors in Amyloidosis Associated with Familial Mediterranean Fever: A Retrospective Analysis
  1. B. Toz1,
  2. S. Tacar2,
  3. E. Oguz1,
  4. M. Erdugan1,
  5. B.A. Esen1,
  6. S. Kamali1,
  7. L. Ocal1,
  8. B. Erer1,
  9. A. Gül1
  1. 1Division of Rheumatology Istanbul School of Medicine, Istanbul University
  2. 2Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul, Turkey

Abstract

Background Familial Mediterranean fever (FMF), the most common form of hereditary autoinflammatory diseases, is associated with increased risk for secondary (AA) amyloidosis

Objectives We herein aimed to investigate the features of FMF patients with amyloidosis with respect to their responses to current therapies

Methods We enrolled FMF patients with amyloidosis who were regularly followed-up for at least 6 months between 1978 and 2015 into the study. Starting times for colchicine, anakinra or canakinumab and treatment responses were noted. Proteinuria (spot urine protein/creatinine ratio) and C-reactive protein (CRP) levels were measured in every three months of follow-up. Partial response was defined as ≥50% decrease in baseline proteinuria accompanied by a normal serum creatinine level, whereas complete response was defined as <0.3 gr/d baseline proteinuria and stable serum creatinine. Correlations between treatment responders and continuously elevated or normalized CRP levels were tested by using a chi-square test

Results We identified 79 FMF patients with documented secondary amyloidosis, and all were on colchicine treatment. Their demographic features are shown in Table 1. Mean time to diagnosis after the first symptom was 10 years. Patients were evaluated for partial and complete response after mean follow-up period of 66±85 months. Response to colchicine was observed in 30/65 patients [partial response in 19 (29%), complete response in 11 (17%)]; and 54% was non-responder to colchicine. Anakinra was added to treatment in 22 patients with inadequate response to colchicine, which resulted in partial response in 12, and complete response in 2. Eight patients with partial response to colchicine also received anakinra for better control of attacks and/or elevated acute phase response, and a complete response was achieved in 3 patients. In 3 patients, anakinra was switched to canakinumab because of local injection site reaction (1 patient) and persistence of proteinuria (2 patients). Among those, two patients had partial response, and another underwent hemodialysis due to progressive kidney failure. No significant association was observed between normalized CRP levels and response to treatment with respect to proteinuria and creatinine levels (colchicine; p=0.67, anakinra/canakinumab;p=0.82). No serious infection requiring hospitalization was detected in association with IL-1 blockade.

Table 1.

Demographic features of FMF patients with amyloidosis

Conclusions Amyloidosis still remains as an important complication of FMF, and a satisfactory response to colchicine could be observed in an important proportion of patients. Treatment with IL-1 inhibitors seems to be an effective and safe option for those patients with an inadequate response to colchicine

Disclosure of Interest None declared

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