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FRI0461 Higher Burden of Disease in Female Psa Patients Compared To Male Patients. Data from The Bepas Cohort
  1. K. De Vlam1,
  2. R. Lories1,
  3. S. Steinfeld2,
  4. F. Van Den Bosch3,
  5. A. Nzeusseu Toukap4,
  6. M. Malaise5,
  7. V. Taelman1,
  8. F. Van Bruwaene6,
  9. M. Vanden Berghe7,
  10. R. Joos8,
  11. J. Lenaerts9,
  12. P. Geusens10,
  13. S. Dall'Armellina11,
  14. I. Peene12,
  15. G. De Branbanter13,
  16. M. Van Den Berghe14,
  17. J. Qu15,
  18. M. Maertens16,
  19. H. Leroi17,
  20. on behalf of BEPAS
  1. 1Rheumatology, University Hospitals Leuven, Leuven
  2. 2Rheumatology, Clinique St Jean, Brussels
  3. 3Rheumatology, Universitair Ziekenhuis Gent, Gent
  4. 4Rheumatology, UCL ST Luc, Brussels
  5. 5CHU Sart Tilman, Liege
  6. 6Rheumatology, Heilig Hart Ziekenhuis, Roeselaere
  7. 7Rheumatology, Algemeen Stedelijk Ziekenhuis, Aalst
  8. 8Rheumatology, ZNA, Antwerpen
  9. 9Reuma Instituut, Hasselt
  10. 10ReumaClinic, Genk
  11. 11Clinique Notre Dame de Grace, Gosselies
  12. 12Rheumatology, AZ St Jan
  13. 13Rheumatology, AZ St Lucas, Brugge
  14. 14Grand Hopital de Charleroi St Joseph, Charleroi
  15. 15Rheumatology, Iris Sud, Bruxelles
  16. 16Rheumatology, AZ Damiaan, Oostende
  17. 17Medical Affairs Immunology, MSD Belgium, Brussels, Belgium

Abstract

Background Psoriatic arthritis impacts significantly function and quality of life. Although radiographic damage may be more important in rheumatoid arthritis both disability and quality of life are similarly impaired in both groups. Only few data in large cohorts are available to evaluate the impact of the articular and skin involvement in PsA. The BEPAS cohort is a unique opportunity to study cross-sectionally and longitudinally these aspects and their effect on disability and quality of life.

Objectives (1) to estimate the severity of disease based on disease activity scores and active inflammation (2) to estimate the impact in terms of health-related quality of life of PsA in Belgium

Methods A cross-sectional analysis at the inclusion visit was performed among all patients included in the BEPAS cohort and subsequently differences between male and female patients were studied. They were evaluated for the demographics, the disease activity at inclusion. Inflammatory parameters were captured at inclusion. HAQ and SF36 patient global assessment and physician global assessment were collected. Gender differences were evaluated by one way ANOVA or Chi –square testing.

Results 461 patients including 263 male patients and 198 female patients with mean age: 52.79 years (±12.29) were recruited in the 17 centers from December 2012 to July 2014.

Conclusions The differences in disease activity and consequently the burden of disease between male and female patients with PsA in the BEPAS cohort seem mainly based on the patient global assessment and enthesitis score. Swollen and tender joint counts as well as inflammatory parameters are not responsible for these differences

Disclosure of Interest K. De Vlam Grant/research support from: MSD Belgium, R. Lories Grant/research support from: MSD Belgium, S. Steinfeld Grant/research support from: MSD Belgium, F. Van Den Bosch Grant/research support from: MSD Belgium, A. Nzeusseu Toukap Grant/research support from: MSD Belgium, M. Malaise Grant/research support from: MSD Belgium, V. Taelman Grant/research support from: MSD Belgium, F. Van Bruwaene Grant/research support from: MSD Belgium, M. Vanden Berghe Grant/research support from: MSD Belgium, R. Joos Grant/research support from: MSD Belgium, J. Lenaerts Grant/research support from: MSD Belgium, P. Geusens Grant/research support from: MSD Belgium, S. Dall'Armellina Grant/research support from: MSD Belgium, I. Peene Grant/research support from: MSD Belgium, G. De Branbanter Grant/research support from: MSD Belgium, M. Van Den Berghe Grant/research support from: MSD Belgium, J. Qu Grant/research support from: MSD Belgium, M. Maertens Grant/research support from: MSD Belgium, H. Leroi Employee of: MSD Belgium

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