Background Spondyloarthritis (Spa) is a rheumatic disease with axial and peripheral inflammatory arthritis. The disease is associated with psoriasis, inflammatory bowel disease and uveitis. Inflammatory biomarkers as Sedimentation rate (SR) and CRP ar not as well correlated with disease activity in Spa as it is in Rheumatoid arthritis. Calprotectin, mainly secreted by neutrophilic granulocytes is elevated in sites of active inflammation Serum or plasma Calprotectin is elevated in rheumatoid arthritis, SLE and in IBD
Objectives To investigate Plasma Calprotectin in Spa patients from Rana, Norway. Is Calprotectin elevated in Spa compared to healthy relatives, and relatives with symptoms of Spa? Is Calprotectin associated to age and gender? Is Calprotectin correlated to body mass index, other markers of inflammation, disease manifestations?
Methods Patients with spondyloarthritis, were recruited from hospital registers, family doctors and by advertisement in local newspaper. Clinical data, Crp and HLAB27 were collected, x-ray and mri of SI-joint was performed if the patient had inflammatory backpain. If they fulfilled the ESSG-critera for Spondylarthritis they were included. The first degree relatives of the included patients were contacted and asked for symptoms of synovitis or inflammatory backpain by questionnaire. Symptomatic relatives were investigated, and included if they fulfilled the ESSG-critera. 387 spondylarthrits patients were included. 273 patients had mri of SI-joints235 patients, 51 symptomatic relatives and 74 healthy relatives were tested for Plasma Calprotectin, by Statistic testing with SPSS Chi square test or Students T-test
Results Calprotectin levels are not significantly different in men and women, in Spa-patients, relatives with symptoms and healthy relatives of Spa patients. In Spa-patients there is no difference in Calprotectin-levels in inflammatory back-pain, radiological sacroiliitis, sacroiliitis on mri, psoriasis, inflammatory bowel disease, acute uveitis, reactive arthritis and HLA B27 positivity. Calprotectin levels are correlated to other inflammatory markers: SR, Crp, Hb and Trc, The best correlation is with Crp. Calprotectin is correlated to swollen joint count but not to BASDAI, BASFI or MHAQ
Conclusions Se-Calprotectin could be a valuable biomarker I Spa, especially in peripheral Spa with polyarthritis
Hansson C, Eriksson C, Alenius G-M. S-Calprotectin (S100A8/S100A9): A Potential Marker of Inflammation in Patients with Psoriatic Arthritis. Journal of Immunology Research. 2014;2014:696415. doi:10.1155/2014/696415.
Acknowledgement CALPRO AS, Arnstein Arnebergsvei 30 1366 Lysaker, Norway for analysing Plasma Calprotectin
Disclosure of Interest None declared