Background Rheumatoid arthritis (RA) is an inflammatory disease characterized by erosive synovitis. Fibromyalgia syndrome (FMS) known with widespread pain, fatigue, sleep disturbances and mood disorders. FMS frequency increased in patients with RA.
Objectives This study aimed to assess the prevalence of FMS in patients with RA and to analyse the relationship between disease activity and FMS.
Methods The study included 151 RA patients and 77 controls without inflammatory rheumatic diseases. RA patients and the control group were evaluated with 2010 ACR criteria for FMS. Participants were divided into 4 groups according to presence of RA and FMS (Group 1: RA+, FMS+; Group 2: RA+, FMS-; Group 3: RA-, FMS+; Group 4: RA-, FMS-). Demographic characteristics, laboratory results, VAS pain, DAS 28, and HAQ scores were compared between 4 groups. RA patients were classified as in remission or without according to the DAS 28 score (DAS 28≤2.6 and>2.6 respectively) and FMS evaluated.
Results The mean age and sex distribution were similar between the RA patients and controls. FMS was found in 35.1% of RA patients and 19.5% of controls (p<0.05). The highest VAS pain and DAS 28 scores were in the group 1 and group 3 between the sub-groups (Table 1). FMS were compared between controls, RA patients in remission and active disease. FMS ratio was 19.5%; 8.1%; 53.9% respectively (p<0.05). Four parameters (ESR, tender joints, swollen joints, patient global assessment) of DAS 28 were higher in RA patients with active disease (p<0.05).
Conclusions FMS is more common in the patients with RA than the general population therewithal FMS found more common in the patients with active RA. When DAS 28 parameters are analyzed, objective values (ESH; swollen joint) were higher as subjective values (pain) in this group. In conclusion increased widespread pain and disruption of the sleep quality because of inflammation may facilitate the diagnosis of FMS.
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Disclosure of Interest None declared