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THU0512 Insulin Resistance as An Independent Predictor of Subclinical Atherosclerosis in Patients with Gout
  1. J.H. Kim,
  2. H. Jeon,
  3. S.H. Kim,
  4. H. Kim,
  5. J. Yoo,
  6. M.K. Chung,
  7. J.H. Koh,
  8. J. Lee,
  9. S.-K. Kwok,
  10. J.H. Ju,
  11. S.-H. Park
  1. Rheumatology, Seoul Saint Mary's Hospital, Seoul, Korea, Republic Of

Abstract

Background Gout is linked with metabolic disorders those are important risk factors of cardiovascular diseases.

Objectives The aim of the present study was to identify independent predictor of subclinical atherosclerosis in patients with gout by measuring presence of atherosclerotic plaque and prevalence of erectile dysfunction (ED).

Methods We analyzed 80 patients with gout and 70 healthy controls. Carotid plaque and ED were assessed by using ultrasound measurement of carotid plaque and the five-item version of the International Index of Erectile Function questionnaire in participants, respectively. Logistic regression analysis was performed to estimate the effect of variables on presences of carotid plaque or ED on all of the study subjects and patients with gout.

Results Gout patients had more ED (55.3% vs. 41.4%, p<0.047) and carotid plaque (59.2% vs. 17.1%, p<0.007) compared to controls. After adjustment of compounding factors, only HOMA-IR was significantly associated with ED (OR: 1.82, 95% CI: 1.05–3.15) whereas was not with carotid plaque (OR: 1.02, 95% CI: 0.99–1.47). Gout showed significant association with carotid plaque after multivariate analysis (OR: 13.39, CI: 1.93–92.88). Older age (p<0.001), higher HOMA-IR (p=0.048) and lower GFR (p=0.038) were observed in patients with presence of ED than without ED in gout patients. And gout patients with carotid plaque were older (p=0.003) and had higher insulin level (p=0.035) and HOMA-IR (p=0.039) than without plaque. Logistic regression analysis showed that HOMA-IR was an independent predictor for the presence of both ED (OR: 1.62, 95% CI: 1.03–2.82) and carotid plaque (OR: 1.40, 95% CI: 1.04–1.63).

Conclusions In our study, insulin resistance was an independent predictor of subclinical atherosclerosis in patients with gout.

Disclosure of Interest None declared

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