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THU0389 Comparing Diffusion Weighted Imaging (DWI) with Clinical Parameters and Short Tau Inversion Recovery (STIR) Sequence in Detecting Spinal and Sacroiliiac (SI) Joints Inflamation in Spondyloarthritis (SPA)
  1. H.Y. Chung1,
  2. C.S. Lau2,
  3. P. Li1
  1. 1Division of Rheumatology and Immunology, Queen Mary Hospital, Hong Kong
  2. 2Division of Rheumatology and Immunology, University of Hong Kong, Hong Kong, Hong Kong


Background DWI has been proposed for SpA diagnosis and disease monitoring1,2. The clinical correlation and effectiveness of this imaging when compared to the traditional STIR sequence is still under evaluation.

Objectives To compare DWI with with clinical features, and traditional STIR sequence in detecting spinal and SI joints inflamation in SpA patients.

Methods One hundred and ten patients fulfilled ASAS Axial SpA criteria were recruited consecutively from two rheumatology centers in Hong Kong. Clinical, radiological and blood parameters were collected. DWI and STIR MRI were performed simultaneously and results were scored according to the Spondyloarthritis Research Consortium of Canada (SPARCC) for comparison. The Apparent Diffusion Coefficient (ADC) values were also calculated.

Results DWI showed no correlation with clinical features. When compare with STIR sequence, it correlated well with STIR sequence at the SI joints level (CC 0.76, p<0.001), but weakly at the spinal level (CC 0.23, p=0.02). At SI joints level, presence of inflammation by both STIR sequence and DWI were associated with increase in maximum (B=0.24, p=0.02 in STIR; B=0.37, p<0.001 in DWI) and mean ADC values (B=0.17, p=0.003 in STIR; B=0.15, p=0.01 in DWI). Maximum (B=0.19, p=0.04) and mean spinal ADC values (B=0.18, p=0.01) were also positively associated with DWI detected spinal inflammation. STIR sequence had no association with ADC values. Presenec of Modic lesion showed positive correlation with STIR (B=7.12, p=0.01) but not spinal ADC values.

Conclusions Both STIR sequence and DWI perform similiarily in detecting active sacroiliitis. At spinal level, ADC values appear to be independent of other imaging/ clinical assessment and are not affected by degenerations.

  1. Gaspersic N, Sersa I, Jevtic V, et al. Monitoring ankylosing spondylitis therapy by dynamic contrast-enhanced and diffusion-weighted magnetic resonance imaging. Skeletal Radiol. 2008 Feb; 37(2): 123–31.

  2. Sahin N, Hacibeyoglu H, Ince O, et al. Is there a role for DWI in the diagnosis of sacroiliitis based on ASAS criteria? Int J Clin Exp Med. 2015 May 15; 8(5): 7544–52.

Disclosure of Interest None declared

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