Article Text

PDF
THU0351 Vitamin D Insufficency Is Associated To Fatigue in Non-Supplemented Women with Systemic Lupus Erythematosus in A Mediterranean Region
  1. T.C. Salman-Monte1,
  2. P. Corzo1,
  3. F. Castro1,
  4. L. Polino1,
  5. V. Torrente-Segarra2,
  6. J. Carbonell-Abello1
  1. 1Rheumatology Department, Hospital del Mar, Barcelona
  2. 2Rheumatology Department, Hospital General Hospitalet-Moisès Broggi, St Joan d'Espi, Spain

Abstract

Objectives It has been previously reported that vitamin D deficiency is more prevalent among SLE patients than in the general population. We sought to determine the prevalence of vitamin D insufficiency and deficiency and their related factors, its relationship to SLE symptoms and disease activity on a group of supplemented and non-supplemented female SLE patients from the Mediterranean region.

Methods We performed a cross-sectional study including female SLE patients who regularly attended the outpatient Lupus Unit at Parc de Salut Mar-IMAS in Barcelona, from January 2012 and May 2014. Collected data were: sociodemographics; vitamin D supplementation; fatigue degree visual analog scale; pharmacological treatment; main SLE serological markers, Indexes, scales; and plasma levels of 25-hydroxy vitamin D

Results One-hundred and two consecutive female SLE patients were included. Vitamin D overall insufficiency and deficiency were exhibited by 46% and 22.5% of patients, respectively. Vitamin D insufficiency was found in 50% of supplemented and 60% of non-supplemented patients. Among non-supplemented female SLE patients, it was found that patients with Vitamin D insufficiency showed more fatigue (p=0.009) and received more oral corticosteroids (p=0.02) than those with normal levels. Patients with Vitamin D insufficiency (supplemented and non-supplemented) received more oral corticosteroids than those without insufficiency (p=0.008).

Conclusions Vitamin D insufficiency is highly prevalent among female SLE patients, even in southern regions. Non-supplemented female SLE patients showed more fatigue and received more oral corticosteroids than those with normal levels of Vitamin D. This data was not found in supplemented patients despite having a high prevalence of Vitamin D insufficiency (up to 50%). Further studies with longer follow-up and larger population are needed to confirm our observations.

Disclosure of Interest None declared

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.